ID S4S1M1_PETMA Unreviewed; 629 AA.
AC S4S1M1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Leucine rich repeat containing 4Ba {ECO:0000313|Ensembl:ENSPMAP00000011363.1};
GN Name=LRRC4B {ECO:0000313|Ensembl:ENSPMAP00000011363.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000011363.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000011363.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR AlphaFoldDB; S4S1M1; -.
DR STRING; 7757.ENSPMAP00000011363; -.
DR Ensembl; ENSPMAT00000011409.1; ENSPMAP00000011363.1; ENSPMAG00000010382.1.
DR GeneTree; ENSGT00940000160261; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR OMA; MWAAMVT; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0097060; C:synaptic membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF8; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 483..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 308..397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 419..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 69519 MW; 582A285EC918B113 CRC64;
TCPAVCSCTQ QFNRVICSRK GLNQVPSGIS NTARVLNLQE NSLKMVQADS FRNLHRLEVL
QLARNAIRQV EVGAFNGLTS LTTLELLDNR LTAIPSGAFE FLSKLRDLWL RNNPIEDISA
YTFTRIPSLQ RLDLGELTKL QFISNEAFEG LSNLRYLNLG MCNLREVPKL SPLVRLEELE
LSGNRIEILR PGSFQGLANL RKLWIMHSEV RLVERNAFDE LQSLKELNLA HNSLMSLPHD
LFSPLQKLER VHLHHNPWTC DCDILWLSWW LRENVPNNAT CCARCALPAD RKAINLWELD
SSRFTCYPPL IEVPPSDVNI SEGMAAELRC RAPSSASSVT WITPNGTSMT HGSYKIRISV
LHDGTLNFTN VTVQDTGIYT CLVANSVGNS TASATLNVTA PDTGTNGYTY FTTVTVETSE
PTRGGARDGR GFTHSPRLTT TPFSLNGPSD ETAVGTRPAA ASASPGDSAS TAGLDEVMKT
TKIIIGCFVA ITLMAAAMLV IFYKLRKQHH RQGRHMIQAR AIEIINVDED VGAGASGTLG
GRHTQQHNPH YLHHASPLGL DLSLGSPKQK NHDGVINPTG LYSTYKPMYG YSNHMGTLNH
TAVNSFHHSI HEPLLIRTNS KENVQETQI
//
