ID S4VR00_9VIRU Unreviewed; 1714 AA.
AC S4VR00;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:AGO82793.1};
GN ORFNames=pdul_cds_650 {ECO:0000313|EMBL:AGO82793.1};
OS Pandoravirus dulcis.
OC Viruses; Pandoravirus.
OX NCBI_TaxID=1349409 {ECO:0000313|EMBL:AGO82793.1, ECO:0000313|Proteomes:UP000201566};
RN [1] {ECO:0000313|EMBL:AGO82793.1, ECO:0000313|Proteomes:UP000201566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Melbourne {ECO:0000313|EMBL:AGO82793.1};
RX PubMed=23869018; DOI=10.1126/science.1239181;
RA Philippe N., Legendre M., Doutre G., Coute Y., Poirot O., Lescot M.,
RA Arslan D., Seltzer V., Bertaux L., Bruley C., Garin J., Claverie J.M.,
RA Abergel C.;
RT "Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of
RT parasitic eukaryotes.";
RL Science 341:281-286(2013).
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DR EMBL; KC977570; AGO82793.1; -; Genomic_DNA.
DR RefSeq; YP_008319462.1; NC_021858.1.
DR GeneID; 16512473; -.
DR KEGG; vg:16512473; -.
DR Proteomes; UP000201566; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd13999; STKc_MAP3K-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF975; DUAL SPECIFICITY PROTEIN KINASE SPLA-RELATED; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AGO82793.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000201566};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000313|EMBL:AGO82793.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 777..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 725..765
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 826..1087
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1451..1703
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1091..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 853
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1478
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1714 AA; 182965 MW; A9EAE14CFAE76058 CRC64;
MDPMTRHRVV TLWVLFLVMS AACAPCAAAV GVRLNGSGTK SAALLFDVLT RGYTFVRDDV
AIRYDAAGSS VATGRSMIQD FDAYELPIDV GLTITYNITQ LPLAGQAVVM AYHLPEFDPA
VDPPLVFDRA TLAAIWAGNV STWNHPAIAA LNQEIAARLP SANITLGYID DFYLSAAEVV
KLSLESFSPA FAVEFVRHNR TFGLLPFVAQ GRGRVLSDSS PDRVAWVADT PYGLTFVDYA
DVPTDDAATV VRAASLYNRA GRLVEPSVGA VQLAMRDFSA DYAVGNLAIP IYDAPGNGSW
PMAYVPLVAL SNRFVQDDCT RISELANFLA WVHTSDGATK AMAALNFAPL DQSLKKRVVD
SLDAILCNYA PSFETDILIG YGTPLSVLTT WANQWSSPTT KATYYETSSA DAVGLQSDYG
GDFGVTTMGA HAAAASGLGQ DRRALPGDLA VVPLAAFALV PAYNVPALAG ATLALDAPTI
AGIYMGEVRT WDDPRIAATN EGLVLPSLPI AVVVHAIDSD INWLLTSWLS DRVPAFADAV
GRSRLPHYPV QDMANASAEV DAVFGVGDAL FDRQGGFALW PQFDVGLISR INAVRAASLV
HAPSGAVVAP GIASVTAALN AYVLANGVDG MTAFDTTVPV ADADAATAWP ATVLVSAAYR
DTTMPDCTKA TALADFFWWT QSDAAALAAA RRQGFAVATT ADPRLAANML DALARFECAG
RKVSALAGCI VDGTLCMNRG TCVPATANAT ARCVCEKGYV GDACEAEESS SGSDSSLVVA
LAVGLPTLAA VLVLAACAAF IVALAVVYRG RRANADSDWE ISYDELEVGE SLGSGGYGEV
RRAVWKGTDV AVKSMSADKI TREMERNFCE EVRVMTSLRH PNVVLFMAAC TKPPNMCIVM
EYMALGSLYE LLHNELIPEL PFVLKAKMAY QASKGLYFLH SSGIVHRDVK SLNLLLDNKW
NVKVSDFGLT KFRADLADGA GTAPIGSVHW MAPEVLDESL DVDYAMADVY SFGIILWEVL
TREQPYAGMS PAAIAVAVIR DGARPLMPAD PTAAHPQAYV DLVHDCWHRD PTVRPTFMEI
MTRLSAMHGE SSSGVGVSSS GSSGNDSAPQ VHAKAKRVDV HHHHTGGSWT LPSTSSVAGT
GDYDTGSSAS AAARSGRADA LAVGAAVGGV RPPEGTMAIV FADVACAVSL WEHDPEAMRD
ATVAYNEALR SLLPAHRGYE SLLAVGARSI GEGTRNTGEG SFCLAFERIS DAVAWCAAAQ
RALLEVQWPR VLLDHPAAAE EWGGADDRVL FCGLRARMGV HVGTPRISRD PATKRVAYVG
PAVDSAARIT ALAHGGQVVL SAAAYKALAD DDNTGAHHWT TRRVGRIDLP DAVSGIHGTL
YELAVPRLEG RFFGAGMIAD SAASSTTSDR GSSRVDGDAT DEDLGLMVDG NEQRYLTSAN
MCRWVIDFAD VQLGTQVGVG SYGVVYRARW KGVDVAVKRF IRQQLDERTL LDFRAETALM
LDLAHPNVVV FIGACVRRPN LCLVTEFIKG GNLRALLADV SVRVAWADRL RLMRTAAAGV
AYLHGRDRPI VHRDLKSSNL LVDDNFTIKV ADFGFARIRE DNATMTRCGT PAWTAPEVLR
GERYSEKADV YSFGVVMWEI ITRKQPYSGR NFMAVTLAVL EGTRLDIPAD CPADLAKLVR
RCWRKNPAKR PSMAEVLADL DAMSGSPDAL SLAV
//