ID S4XKX1_SORCE Unreviewed; 1245 AA.
AC S4XKX1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SCE1572_00460 {ECO:0000313|EMBL:AGP33101.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP33101.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP33101.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP33101.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP003969; AGP33101.1; -; Genomic_DNA.
DR RefSeq; WP_020464805.1; NC_021658.1.
DR AlphaFoldDB; S4XKX1; -.
DR STRING; 1254432.SCE1572_00460; -.
DR KEGG; scu:SCE1572_00460; -.
DR PATRIC; fig|1254432.3.peg.101; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_1_1_7; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 14..464
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 476..795
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1245 AA; 134777 MW; FAE729B63C7A8F35 CRC64;
MSADAARARG ARELADEPAR RRIREDLRTT LVVEAAAGTG KTTALVSRIV AVLRKAPEEG
GGTLDRIVAV TFTEKAAGEM KLRLRAEIER ARGDAASGPA ERARLDEALA HLEAARIGTI
HSFCADLLRE WPVEARVDPL FQVAAADQAE ALFDQAFDAW FQRTLNDPPE GVRRILRRRP
RDGAQGPRDL LRSAAWRLAE HRDFTRPWRR DPFDRERAID ELLDRLAALA DLGAEADREG
DYLAQSLRNI ERYLAELRRR EEVTGGRDHD GLEAELGELA RWKEWRWKGS GKAFGADLSR
AEVLAQRDRV KVELDAVLTA ASADLAACLS RELRPPIEAY DALKARAGKL DFLDLLLCAR
NLLRSSRAVR EELNLRFSHL FVDEFQDTDP LQAEILLLLA ADDPAETDWT RARPVPGKLF
VVGDPKQSIY RFRRAEVALY EATKARLVAC GASVLYLSTS FRSAPSIQEA VNAAFAPLMQ
GGSGEGAASQ ARYVALGPFR DDPVGQPTVI ALPVPRPYGD FGKISDFRVR QSIPDAVGAF
VHHLIHGGRG AAGGRRWTVT ERERPGQRVP LEARHICLLF KRFQTFGEDA TRAYVRALEA
RRIPHVLVGG RSFHDREEVM AVRSALLAIE WPDDELSVYA TLRGPLFALT DDVLLLYRDR
FQRLHPLAQP DGGALDLAVE GGARPLWEVA EALAVLGRLH RERNRRPIAD TIGGLLDETR
AHAGIAIWPT GEQALANVLR VMDLGRRFEA GGATSFRAFV ERLEADAERG EVAEAPVVEE
GTEGVRIMTV HRAKGLEFPV VILADPASPA VHQHPSRHVD PELGLWAEPL AGCVPAELVE
RRDEVLRRDR EEAVRLAYVA ATRARELLVV PAVGDARPGD GSSDGWLDVL HPVLYPAPRD
RRSARRCEDL GCPPFGADTV LERPARCEAD ERDAVAPGEH APMAGSHRVV WWDPSTLDLD
REPEAGLRQQ RILQADASGA GAAAGAGAAA GAVATAGAAV AAGAGVAAGA GVAVGEIGQR
GYEVWLEARQ RAIRDGAVAA IRVKTATQIS HEAAAEAAAG AAGGAQQRSG AAGTARADAL
PVISFEQTAI AREGRPYGKR FGTLVHAVLA EVDLRADEDE VRTVAAAQAR LLGAPAEEVD
AAVAAAVAAL EHPLLRRAAE SAARGACERE TPLLLRLEDG TIAEGVVDLS FRESVGDVGV
WTVVDFKTGS DAGTAHAAQE AQVRLYVQAI AEATGERARG VVLRV
//
