ID   S4Y3B5_SORCE            Unreviewed;       499 AA.
AC   S4Y3B5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   ORFNames=SCE1572_24545 {ECO:0000313|EMBL:AGP37378.1};
OS   Sorangium cellulosum So0157-2.
OC   Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX   NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP37378.1, ECO:0000313|Proteomes:UP000014803};
RN   [1] {ECO:0000313|EMBL:AGP37378.1, ECO:0000313|Proteomes:UP000014803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=So0157-2 {ECO:0000313|EMBL:AGP37378.1,
RC   ECO:0000313|Proteomes:UP000014803};
RX   PubMed=23812535; DOI=10.1038/srep02101;
RA   Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA   Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT   "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT   milieu.";
RL   Sci. Rep. 3:2101-2101(2013).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003969; AGP37378.1; -; Genomic_DNA.
DR   AlphaFoldDB; S4Y3B5; -.
DR   STRING; 1254432.SCE1572_24545; -.
DR   KEGG; scu:SCE1572_24545; -.
DR   PATRIC; fig|1254432.3.peg.5567; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_10_7; -.
DR   Proteomes; UP000014803; Chromosome.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          17..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   499 AA;  52858 MW;  4C09ABB6DF73ED20 CRC64;
     MIKKLQNYVG GKMTNSSTQR WGDVFNPALG AVTSQVPMST AGEVSSAVLV AKQAFEGWSA
     TPPVRRARVM FELKSLIDRH VDELAALVTA EHGKVLDDAR GSVTRGMEVV EFAAGIPQLL
     KGEYSEGVAR GVDSWSFRQP LGVCAGVGPF NFPAMIPLWM APIAIACGNT FIMKPSEKVP
     SLSLRLAELW TQAGLPPGVF NVVSGDKEVV DALIEHPDVA AISLVGSTPV AEDVYQRATR
     AGKRVQALGG AKNHMIVMPD ADLSHTVDAL MGAAYGSAGE RCMAISVAVA VGPGTGDRLV
     DALIPKIKAL KIGPGDQPGL DMGPLVTKQH LEKVSGYVDL GVKEGARLLV DGRGLKVPGS
     ENGFFLGGCL FDHVTSSMKI YQEEIFGPVL AVVRVPTLDA AIQLVNAHRY GNGGAIFTSS
     GEAADEFTKR IQIGMVGVNV PIPVPMAFHS FGGWKGSLFG DHYMHGPEGV RFFTRLKTVT
     SRWPRGASVG ASFAMPTVK
//