ID S4Y7E5_SORCE Unreviewed; 790 AA.
AC S4Y7E5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AGP40794.1};
GN ORFNames=SCE1572_43695 {ECO:0000313|EMBL:AGP40794.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP40794.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP40794.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP40794.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP003969; AGP40794.1; -; Genomic_DNA.
DR RefSeq; WP_020740591.1; NC_021658.1.
DR AlphaFoldDB; S4Y7E5; -.
DR STRING; 1254432.SCE1572_43695; -.
DR KEGG; scu:SCE1572_43695; -.
DR PATRIC; fig|1254432.3.peg.9875; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_7; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 8..198
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 202..301
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 790 AA; 85676 MW; FF1A9EF1FC50BC65 CRC64;
MTKPIRRAGV IGAGVMGSGI AAHFANAGIE VLLLDIVPPN LTDAERKDPA ARSRFAAGGL
EKALKARPAA FFHPSHARLV RTGNTEDHFA ELAQCDLVIE AIIEKMEPKR ALFARLEQVM
RKDAIAASNT SGLRIEEMMQ GRSEDFRKRF LVMHFFNPVR YMKLLELVAG PDTDPAVVAR
VRKFGEDVLG KGIVFGKDTP NFVGNRIGTH AMLTAIHLMV EDGLAPEDVD AITGVAMAHP
KSASFRTGDI VGLDTFAHVA DNCYTALERD EDREVFKVPA YIRSMIEAKL LGDKTKGGFY
RKAKEGLETL DPAKLQYRPH GGDEAMKKAT KSCEKVEDPA ARVKKLANDP GKAGQFAWKV
LSRSLAYTAR RVGEIADSIV AIDDAMRWGY NWELGPFQTW DALGFAETVE RMQKDGIKLP
ESILRMKQSG ATSFYRQDGA VFDLLKGEYV AREVDPRNVT LAGARRGVKP VLANDGAEAW
DLGDGVLGVT FKTKANSLDP DSIGMLSLAA EKAEQDFRAL VVFNQGEHFC VGANLFLVVM
AAGNKDWEAI RKMVKGYQDA TQRLKYASVP VVAAPYGMTL GGGLELCFAC DAVQAAAETY
AGLVEVGVGL IPGGAGTLNM LWRAFEGIPE GVPVNSYDLV TQVFKNIALA KVATSADEAK
ALGFFRKTDG VSFDRARQLH EAKARAVGLA EAGYHAPVPR AYKLPGESGI ATLQMMIDTL
VAGGHASEHD AKIARKLAEV LCGGAGGAAR EVTEEEILEL EREAFVSLCG EPKSAERMQY
MLMNNKPLRN
//
