ID S5LVU9_9MOLU Unreviewed; 811 AA.
AC S5LVU9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=gyrA {ECO:0000313|EMBL:AGR40701.1};
GN ORFNames=STAIW_v1c00040 {ECO:0000313|EMBL:AGR40701.1};
OS Spiroplasma taiwanense CT-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276220 {ECO:0000313|EMBL:AGR40701.1, ECO:0000313|Proteomes:UP000014984};
RN [1] {ECO:0000313|EMBL:AGR40701.1, ECO:0000313|Proteomes:UP000014984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT-1 {ECO:0000313|EMBL:AGR40701.1};
RX PubMed=23873917; DOI=10.1093/gbe/evt108;
RA Lo W.S., Ku C., Chen L.L., Chang T.H., Kuo C.H.;
RT "Comparison of metabolic capacities and inference of gene content evolution
RT in mosquito-associated Spiroplasma diminutum and S. taiwanense.";
RL Genome Biol. Evol. 5:1512-1523(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP005074; AGR40701.1; -; Genomic_DNA.
DR RefSeq; WP_020833840.1; NC_021846.1.
DR AlphaFoldDB; S5LVU9; -.
DR STRING; 1276220.STAIW_v1c00040; -.
DR KEGG; stai:STAIW_v1c00040; -.
DR PATRIC; fig|1276220.3.peg.4; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_6_1_14; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000014984; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000014984};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 13..465
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 437..464
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 811 AA; 92419 MW; 7227AC35416786A0 CRC64;
MSEVFNKGRI LEIDIKNEVE KDFLEYSMSV IVSRALPDLR DGLKPVHRRI IYAMNDLKIT
ADTPHKKSAR IVGEVIGKYH PHGDSSVYEA MVRMSQDFSY RYPLVEGHGN FGSIDGDGAA
AMRYTEARLS KISSMLLKDI DMNTVPYIDN YDASEQEPKY LTGYFPNLLV NGATGIAVGM
ATSIPPHNLI EVINATIEYI KNNNITIEEI LKFIKGPDFP TGALMTNGKN MIEGYKTGKG
NLTIRAKIDI EETNKNQKII ISEIPYQTNK LKIVEKIAEL YKNKIITGIS DIRDESNYEG
IRIVLEFSKN SNPQLIIKRL YKFTNLQSNF TINMLSLHNG IPVVLNIKEI IKFYVKFQIE
IILKRSIFEK EKLEAKLHIL NAIRTAVDHI DEIIKIIKNS NTTEIAYKKL FDNFNFDEKQ
SKAILDMRLQ RLVGLEREKI ENDINNIELR IKELIKILES KEEQNILLID QLEYIKNKFG
DERRTKIIEE DDIQIDDEEL IQDTQMILTL SEEGYIRRLQ PEEFKTQKRG GKGIIINSNL
DDNILIAKMG KTKDDVLFFS NEGKVYKLKG YNITQFLRTS RGVPIINFIG INFSEKVSSV
LTFRNKKNNY KYLVFVTKKG IVKKVNLEEF NKINNFGKIA IHLDKEDSLI SVIPTSGLDK
ILIATKNGKV SKINESDFRP MSRSSRGVKG ITLDKTDEVI SSCTDFKNDC VVTISEKGII
KKTLISEYNN FNRGAKGVVG MKLNDKTGKL KSVLAIRETD EVLMISSKGK IIKIHSQEIK
MQSRNTSGVI GFNLEDDEKI TAVTLEWNKG D
//
