GenomeNet

Database: UniProt
Entry: S5LXF4_9MOLU
LinkDB: S5LXF4_9MOLU
Original site: S5LXF4_9MOLU 
ID   S5LXF4_9MOLU            Unreviewed;       445 AA.
AC   S5LXF4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   Name=pdhC {ECO:0000313|EMBL:AGR42494.1};
GN   ORFNames=SDIMI_v3c07900 {ECO:0000313|EMBL:AGR42494.1};
OS   Spiroplasma diminutum CUAS-1.
OC   Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC   Spiroplasma.
OX   NCBI_TaxID=1276221 {ECO:0000313|EMBL:AGR42494.1, ECO:0000313|Proteomes:UP000014983};
RN   [1] {ECO:0000313|EMBL:AGR42494.1, ECO:0000313|Proteomes:UP000014983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CUAS-1 {ECO:0000313|EMBL:AGR42494.1};
RX   PubMed=23873917; DOI=10.1093/gbe/evt108;
RA   Lo W.S., Ku C., Chen L.L., Chang T.H., Kuo C.H.;
RT   "Comparison of metabolic capacities and inference of gene content evolution
RT   in mosquito-associated Spiroplasma diminutum and S. taiwanense.";
RL   Genome Biol. Evol. 5:1512-1523(2013).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938,
CC         ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP005076; AGR42494.1; -; Genomic_DNA.
DR   RefSeq; WP_020836722.1; NC_021833.1.
DR   AlphaFoldDB; S5LXF4; -.
DR   STRING; 1276221.SDIMI_v3c07900; -.
DR   KEGG; sdi:SDIMI_v3c07900; -.
DR   PATRIC; fig|1276221.3.peg.792; -.
DR   eggNOG; COG0508; Bacteria.
DR   HOGENOM; CLU_016733_10_0_14; -.
DR   InParanoid; S5LXF4; -.
DR   OrthoDB; 9805770at2; -.
DR   Proteomes; UP000014983; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06849; lipoyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW   Pyruvate {ECO:0000313|EMBL:AGR42494.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014983};
KW   Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:AGR42494.1}.
FT   DOMAIN          1..76
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          140..177
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
SQ   SEQUENCE   445 AA;  47549 MW;  E0C867E5365F365D CRC64;
     MFKVKFADIG EGLTEGTVTE VLVKMGDEVK MGDALFNVET DKVTSDIYAP VDGKIAKILI
     SANQEINVGD VVIEIDDGKG DSVEEPKAET KVEPVEENAS VVGATPVSNE VISRIAREVA
     PNQSLSNQPS IIDNSNVDVK ASPLARKVAA VMGVDLSKVS PSGPNGRILV ADVESFSANP
     QVASTPTAPQ MVAQKGPAID YSNPLISVPE INEPLTFESK PWNPIRKATV KAMATAHEKV
     AGFTGLRNLD ITELVNIRKQ LKGHADSLRV KLTYLAFIIK ASANALRDMP NLNVRIDEEN
     KATKFAQQIN IGMACDTPDG LMVPVIKGAD KLSVLQIAVK INDLAIKARS KKLASSEMSG
     ATFTVTNFGA VGLDYATPIV NFPESAILGV GTITRAPGVI NDEIEVRDYM PFSITADHKV
     IDGADAGRFL TRIAYYLQNP ATLLV
//
DBGET integrated database retrieval system