GenomeNet

Database: UniProt
Entry: S5RRC4_SALSA
LinkDB: S5RRC4_SALSA
Original site: S5RRC4_SALSA 
ID   S5RRC4_SALSA            Unreviewed;      1176 AA.
AC   S5RRC4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
DE            EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
GN   Name=LOC106601287 {ECO:0000313|RefSeq:XP_014048861.1,
GN   ECO:0000313|RefSeq:XP_014048862.1};
GN   Synonyms=LOC106597276 {ECO:0000313|RefSeq:XP_014043958.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|EMBL:AGS07433.1};
RN   [1] {ECO:0000313|EMBL:AGS07433.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23872231; DOI=10.1016/j.dci.2013.07.008;
RA   Sobhkhez M., Hansen T., Iliev D.B., Skjesol A., Jorgensen J.B.;
RT   "The Atlantic salmon protein tyrosine kinase Tyk2: molecular cloning,
RT   modulation of expression and function.";
RL   Dev. Comp. Immunol. 41:553-563(2013).
RN   [2] {ECO:0000313|RefSeq:XP_014043958.1, ECO:0000313|RefSeq:XP_014048861.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014048861.1,
RC   ECO:0000313|RefSeq:XP_014048862.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001149,
CC         ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
CC   -!- SUBCELLULAR LOCATION: Endomembrane system
CC       {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004184}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. JAK subfamily. {ECO:0000256|PIRNR:PIRNR000636}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KF021282; AGS07433.1; -; mRNA.
DR   RefSeq; XP_014043958.1; XM_014188483.1.
DR   RefSeq; XP_014048861.1; XM_014193386.1.
DR   RefSeq; XP_014048862.1; XM_014193387.1.
DR   STRING; 8030.ENSSSAP00000032281; -.
DR   PaxDb; 8030-ENSSSAP00000032281; -.
DR   GeneID; 106601287; -.
DR   KEGG; sasa:106597276; -.
DR   KEGG; sasa:106601287; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa03.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-UniRule.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0097677; F:STAT family protein binding; IPI:AgBase.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IMP:AgBase.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR041155; FERM_F1.
DR   InterPro; IPR041046; FERM_F2.
DR   InterPro; IPR041381; JAK1-3/TYK2_PHL_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
DR   InterPro; IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
DR   PANTHER; PTHR45807:SF6; NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2; 1.
DR   PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR   Pfam; PF18379; FERM_F1; 1.
DR   Pfam; PF18377; FERM_F2; 1.
DR   Pfam; PF17887; Jak1_Phl; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   PIRSF; PIRSF000636; TyrPK_Jak; 1.
DR   PRINTS; PR01823; JANUSKINASE.
DR   PRINTS; PR00109; TYRKINASE.
DR   PRINTS; PR01827; YKINASETYK2.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00219; TyrKc; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|PIRSR:PIRSR000636-
KW   2}; Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000636};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000636,
KW   ECO:0000256|PIRSR:PIRSR000636-2};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000313|EMBL:AGS07433.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000636};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW   ECO:0000256|PIRNR:PIRNR000636}.
FT   DOMAIN          26..421
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          584..865
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          884..1169
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1010
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
FT   BINDING         890..898
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT   BINDING         917
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1176 AA;  133455 MW;  7C2ADCA4180BEA9C CRC64;
     MMSRSGRFKS TRTGSSTGQC EPPQGPGVHV YLFWTKGGER YLTHTEGKVT AEELSISAAQ
     TVGITPLCHV LFSLYDPESH CWYSPNHFFN SEEQTRLTLH YRMRFYFRNW HGLSEKEPSV
     VRYAPRSGTE HGGSPLLEMT SLEYLFCQAK FDFVNDVTPM EDAQGKEELS RFKNESLGMA
     VLHLSHQALR SGCTLQEVAK SVSFLRCIPR SFAKHIARDN FLTKIRIRRV FADFVRTFQE
     HTVDVGRLGS QEVMYKYLST LEHLAPRFGT ETFLAAHLEL RTDGGDGSGS YLNTSRAHGA
     SDPENVGPQV MHEVMVSGTK GIQWRKMTVQ KPQANSYFGN DYLGNRKSVK QSPLQQEPTS
     SDTWTSFCDF PEISHITITG ANVSIIKQDN FSMEVQMNSS LEALSFVSLL DGYFRLTADA
     HHYLCHEVAP PRVVLSATNG LHGPMNDDFV LQRLRKEAVE EGAFLVRWSV LDYHRIILAV
     LNKSQNGQAA IHKQFRILHS GSVFALEGWD REFSSVKELT DSLKAFVLKS GTDNFTVKKC
     CLPRPAELSN LLVMRQGVDQ CVQPDSVALC LTQLKFHQIK DKEITQEQHL GRGTRTNIYS
     GRLLVWGGAE EDEEDKWNNN LTDRKEIRVV LKILDQSHKD IALAFFETAS LMSQVSHSHL
     VFVHGVSVKG SENIMVEEFV EFGPLDVFLR RERALVTPQW KFTVAKQLAS ALSYLETKQL
     VHGNVCGKNI LVARRGLEEG TFPFVKLSDP GIALNVLSRE ERVERIPWIA PECVPSSAPF
     GRAADQWSFG ATLLEICNNG DLPMSGSTLT EKERFYETRS RLTEPSSQEL ASFISMCLTY
     EPRERPSFRT VLRELTELQL KNPDISPLES LPDADPNVFL KRYLKKIRDL GEGHFGKVML
     YVYDPANDGT GDYVAVKALK HEGGSHLHEG WMKEIEILKS LYHSNIVKYK GCCSELGGQT
     VQLIMEFLPL GSLREYLVKH RLGVAHSLLF AQQICQGMDY LHSKRYIHRD LAARNVLVEN
     EHLVKIGDFG LTKYIPEGDV YYRVREDGDS PVYWYAIECL KESKFSFSSD IWSFGVTLYE
     VLTHGDHRQS PPVKFTQMMG NVHGQMTVMV LVKLLEKHNR LPCPRDCPSE VHMLMQHCWD
     FDPARRPSFK SLIESIGAIR KTYERQPNMR LAQISQ
//
DBGET integrated database retrieval system