ID S5THF5_9CORY Unreviewed; 1225 AA.
AC S5THF5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=B841_04410 {ECO:0000313|EMBL:AGS34361.1};
OS Corynebacterium maris DSM 45190.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1224163 {ECO:0000313|EMBL:AGS34361.1, ECO:0000313|Proteomes:UP000015388};
RN [1] {ECO:0000313|EMBL:AGS34361.1, ECO:0000313|Proteomes:UP000015388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Coryn-1 {ECO:0000313|Proteomes:UP000015388};
RA Schaffert L., Albersmeier A., Kalinowski J., Ruckert C.;
RT "The complete genome sequence of Corynebacterium maris Coryn-1 (=DSM
RT 45190).";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP003924; AGS34361.1; -; Genomic_DNA.
DR AlphaFoldDB; S5THF5; -.
DR STRING; 1224163.B841_04410; -.
DR KEGG; cmd:B841_04410; -.
DR PATRIC; fig|1224163.3.peg.881; -.
DR eggNOG; COG1197; Bacteria.
DR HOGENOM; CLU_005122_2_0_11; -.
DR Proteomes; UP000015388; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000015388}.
FT DOMAIN 662..823
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 848..998
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1206..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1225 AA; 134714 MW; 28F03DCAC467C032 CRC64;
MAAKTTKADP AMLAGLLKVA ATDPKLKGLA GNVGQRRLHI EAIDQARPWT IGTLAHHAPV
LVVTATGREA EDLAAELRAM MGDKVAWFPS WETLPHERLS PGADIVGRRA EILHNLADYR
VVVTAARGFC QPILERAEGR APIVLAEDEE HDLGEITDQL VFRAYSHVDL VAKRGEFAVR
GGILDVFPTT LDHPVRVEFW GDEITDVRQF SVADQRTLDD VEVGRVEIYP ARELPVTDDV
AARARALSTQ YPGNATLVEL LTKLGDRIPA DGMEALIPVL SDSPLVTLPD FLPEDAHVLL
IAPEKIRTRI ADLESTDAEF LAAGWEAAAM GASGPIAAEG LDLSASSYRS FEELEEAARD
NGTPWWTFAP PGMFAADEAA TLPLEYEPGP APRGADQEIA AMMAELRAHT TAGGRAAFIA
PAEGAIKRMV ERFREQGVPA KVATPGWEPT PGEITLYQAL SHAGLVFPKV RKHKDAEALP
LVVVTETDLT GNRVGDIAGA KRRPAKRRNR VDPLALKTGD YVVHETHGIG RFLKMAERTI
NTGDETSRRE YIVLEYAPAR RGQPADQLWV PMESLDILSK YSGGEAPTLS KMGGSDWKNT
KKKARAAVRE IAGELVELYA KRQAAPGRKF GPDTPWQAEM EDNFPFVETE DQMEAIEAVK
HDMERTTPMD RVIVGDVGYG KTEVAVRAAF KAVQDGTQVA VLVPTTLLAQ QHTKTFIQRM
DGFPITIREL SRFTSTAESK EILSGLADGS VDVVIGTHRL LQTGVNWKNL GLIIVDEEQR
FGVEHKEHIT ALRSHVDVLT MSATPIPRTL EMSMSGIREM TTMLTPPEDR HPVLTYVGAY
EDKQVAASIR RELLRDGQVF FIHNKVADIE KKARELRDLV PEARIVVAHG QMSEEQLERT
VQGFWDREYD VLVCTTIVET GLDIANANTL IVENAHHMGL SQLHQLRGRV GRSRERGYAY
FLYPKGATLS ETSYDRLATI AQNNDLGAGM AVAQKDLEMR GAGNVLGAQQ SGHIAGVGFD
LYVRLVGEAV EAYKALAKGE TIDATDQAPK EIRIDLPVDA HIPESYINSE RLRLEIYRKI
ASSKDNTDLQ LIVEEMEDRY GPVPEEVSRL LAVARLRHQA RRAGVTDIGV QGTRIKVHPV
ELADSKQVRL KRLFPGSNYR AAAKAIQLSF PKAGRNVTAP KLRDEELLQW MADFLSSMFD
VDATDVTGGE GKKKARKGKV FSVSE
//
