ID S5VD12_STRC3 Unreviewed; 822 AA.
AC S5VD12;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=B446_31550 {ECO:0000313|EMBL:AGS73114.1};
OS Streptomyces collinus (strain DSM 40733 / Tue 365).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS73114.1, ECO:0000313|Proteomes:UP000015423};
RN [1] {ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RA Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT "The complete genome sequence of Streptomyces collinus Tu 365.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGS73114.1, ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RX PubMed=24140291; DOI=10.1016/j.jbiotec.2013.10.004;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Iftime D.,
RA Musiol E.M., Blin K., Wohlleben W., Puhler A., Kalinowski J., Weber T.;
RT "Complete genome sequence of the kirromycin producer Streptomyces collinus
RT Tu 365 consisting of a linear chromosome and two linear plasmids.";
RL J. Biotechnol. 168:739-740(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP006259; AGS73114.1; -; Genomic_DNA.
DR RefSeq; WP_020943523.1; NC_021985.1.
DR AlphaFoldDB; S5VD12; -.
DR STRING; 1214242.B446_31550; -.
DR KEGG; sci:B446_31550; -.
DR PATRIC; fig|1214242.5.peg.6464; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_2_1_11; -.
DR Proteomes; UP000015423; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015423};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 487..810
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 822 AA; 88146 MW; AF9D95F3AA16FC4D CRC64;
MNKDANDSFV HVRGAGENNL RNIDVDVPRD AMVAFTGVSG SGKSSLAFGT LYAEAQRRYF
ESVAPYARRL LQQVGAPHVQ EITGLPPAVA LQQRRGAPSS RSTVGTLTTL SNLLRILYSR
AGTYPPGAAR LDAESFSPNT AAGACPECHG LGVVHDVAED LLVPDPSLSI REGAIAAWPG
AWQGANLRSV VNGLGIDIDR PWRRLRKKDR DWLLYTDEQP SVYIEPEEDR VDYGYQGKFW
SARKHVMHVL ADSKSEKMRE RALRFVRSVP CPACHGSGLR PEALAVTFAG RSIAEINAMP
LAEVVALLRP VAGRSEADAT TSTARSGETT EVAVRICGDL VARIDVLLDL GLGYLSLGRR
STTLSPGEAQ RLRIATQLRS GLFGVVYVLD EPSAGLHPAD AEPLLDVLDR LKAAGNSLFV
VEHDMDVVRR ADWVVDIGPG AGEGGGRVLY SGPVAGLERV GESATSRYLF GRAEPLDHRP
RAPHGWLHLR GVSRHNLHDV SVDVPLCVLT AVTGVSGSGK STLVTQVLAE VVRGHLGLVP
EEPDEAQLEV DVQDASGVES FDRLVLVDQR PIGRTPRSNL ATYTGMFDAV RKLYAATDEA
RARGYPAGRF SFNVPEGRCE TCQGEGFVAV ELLFLPGTYA PCPTCEGARY NAETLEVTYR
GKNIAEVLAL SVDAAAEFLS CVPAASRSLE TLREVGLGYL RLGQPATELS GGEAQRIKLA
TELQRARRGH ALYLLDEPTA GLHPSDIALL LRQLHRLVDA GNTVVLVEHD LDTIATADWV
IDLGPGGGDA GGRVVAAGPP AKVAKARRSA TAPYLAARLA HS
//
