ID S5VLA5_STRC3 Unreviewed; 506 AA.
AC S5VLA5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Betaine aldehyde dehydrogenase {ECO:0000313|EMBL:AGS71342.1};
GN ORFNames=B446_22650 {ECO:0000313|EMBL:AGS71342.1};
OS Streptomyces collinus (strain DSM 40733 / Tue 365).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS71342.1, ECO:0000313|Proteomes:UP000015423};
RN [1] {ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RA Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT "The complete genome sequence of Streptomyces collinus Tu 365.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGS71342.1, ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RX PubMed=24140291; DOI=10.1016/j.jbiotec.2013.10.004;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Iftime D.,
RA Musiol E.M., Blin K., Wohlleben W., Puhler A., Kalinowski J., Weber T.;
RT "Complete genome sequence of the kirromycin producer Streptomyces collinus
RT Tu 365 consisting of a linear chromosome and two linear plasmids.";
RL J. Biotechnol. 168:739-740(2013).
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway; betaine from betaine aldehyde: step 1/1.
CC {ECO:0000256|ARBA:ARBA00037921}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP006259; AGS71342.1; -; Genomic_DNA.
DR RefSeq; WP_020941774.1; NC_021985.1.
DR AlphaFoldDB; S5VLA5; -.
DR STRING; 1214242.B446_22650; -.
DR KEGG; sci:B446_22650; -.
DR PATRIC; fig|1214242.5.peg.4638; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_0_11; -.
DR Proteomes; UP000015423; Chromosome.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43860; BETAINE ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43860:SF2; BETAINE ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000015423}.
FT DOMAIN 19..492
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 506 AA; 54024 MW; 24A668007B4B443A CRC64;
MADRTERQAR ATIHAGGEWL EAVSGATRDI LDPADARPFA VVAEGDEKDA ERAVAAARQA
FDHGPWPGTP VAERAALLRR VAGLLVRDRE RLGLLESRDA GKTAEEGRVD IDCVADAFRY
FADLVAAEAP GRVVDAGSPD VHSVVVHEPV GVCALITPWN YPLLQASWKI APALAAGNTF
VIKPSEITPM TTIALLELLT EAGLPDGVAN LVTGPGHTVG ARLAEHPGVD LVSFTGGLAS
GTKVAQAAAP TVKKVALELG GKNPNVVFAD ACATEEGFDT AVDQALNAAF IHSGQVCSAG
GRLIVEESVR DRFVAELARR AQRIRLGRGT EDGVECGPLV SEQQRAKVEA YVASALAEGA
VLRCGGRRPE PAPERPESGY FYEPTVLDAC HREMKVVREE VFGPVLTVET FRTEEEAVFL
ANDTEYGLAG AVWTADAGRA RRVAGRLRHG TVWINDFHPY LPQAEWGGFG RSGTGRELGP
AGLAEYRETK HVYQNLAPKP VRWFAG
//
