ID S5Y166_9CAUD Unreviewed; 608 AA.
AC S5Y166;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=DNA polymerase I {ECO:0000313|EMBL:AGT13904.1};
GN Name=45 {ECO:0000313|EMBL:AGT13904.1};
GN ORFNames=WHEELER_45 {ECO:0000313|EMBL:AGT13904.1};
OS Mycobacterium phage Wheeler.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Fromanvirus.
OX NCBI_TaxID=1383054 {ECO:0000313|EMBL:AGT13904.1, ECO:0000313|Proteomes:UP000015570};
RN [1] {ECO:0000313|EMBL:AGT13904.1, ECO:0000313|Proteomes:UP000015570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Harris R.J., Essack N., Kader F., Larsen R., Mbanjwa M., Robertson K.,
RA Thwala T., Mbhele L., Mbisi Z., Mkhwanazi S., Mvubu N., Naicker R.,
RA Ncube M., Wilson T., Mayer O., Jain P., Larsen M.H., Jacobs W.R.,
RA Rubin E.J., Russell D.A., Bowman C.A., Hendrix R.W., Jacobs-Sera D.,
RA Hatfull G.F.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KF416340; AGT13904.1; -; Genomic_DNA.
DR RefSeq; YP_008410824.1; NC_022070.1.
DR GeneID; 16547799; -.
DR KEGG; vg:16547799; -.
DR OrthoDB; 14842at10239; -.
DR Proteomes; UP000015570; Genome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Reference proteome {ECO:0000313|Proteomes:UP000015570};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 15..192
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 372..555
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 608 AA; 67731 MW; 8BA64B257B7D6C54 CRC64;
MKQHRYQIKD ETVLVNVVEH EDDLDGFESF IRSNLRILGL DTETTDLGIY KPDFGIRLIQ
FGNPWESWVL PVERGGVFVG AAVTALQKVQ RFVIHNAAFD LQVIERTLGV PMEQMWPKVE
DTKIYSHLVD PRAYKEGGTG HKLEELTKFY IDPVTAEEVK ASMARLAKKH KTTKDKIWAL
VDLDDPDYEL YAGMDTILVS RLLGKVAPLV PESSHKLIPY EHKLAEVMSY VERTGFLLDV
DYSEKLSADM LRKSEHYTAV ARYAYGVDSV NSTEKLADGL ERTGVKIKGR TATGKRQVNA
ELLEALAEEG NALAKAAIEA KKWGSWEKTW VRNFIERRDA NDRVHPGINP LQARTARMST
NNPSAQNLPA GDWMVRRCFL ADPGQLMVSV DYQAQELRVL AALANDRTMI QAFKDNADLH
QITADASGVD RKVGKMVNFA YVFGSGPSTI AAQAGITFPE AKRVIAGFEQ SYPEVTALSK
SLQREAANLG YVITPTGRRL PVDPDRGYAA LNYMVQSTSR DVTASAVLRL HEAGMTPMIR
LVIHDEVLAS VPEVEAEVTA KEIGRIMEQT FRGVLINTDP EVGGRSWGAA YLKKDEQPSA
DPFLRIPA
//
