ID S5YH64_PARAH Unreviewed; 460 AA.
AC S5YH64;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN ORFNames=JCM7686_pAMI4p117 {ECO:0000313|EMBL:AGT10808.1};
OS Paracoccus aminophilus JCM 7686.
OG Plasmid pAMI4 {ECO:0000313|EMBL:AGT10808.1,
OG ECO:0000313|Proteomes:UP000015480}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=1367847 {ECO:0000313|EMBL:AGT10808.1, ECO:0000313|Proteomes:UP000015480};
RN [1] {ECO:0000313|EMBL:AGT10808.1, ECO:0000313|Proteomes:UP000015480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 7686 {ECO:0000313|EMBL:AGT10808.1};
RC PLASMID=Plasmid pAMI4 {ECO:0000313|Proteomes:UP000015480};
RX PubMed=24517536; DOI=10.1186/1471-2164-15-124;
RA Dziewit L., Czarnecki J., Wibberg D., Radlinska M., Mrozek P., Szymczak M.,
RA Schluter A., Puhler A., Bartosik D.;
RT "Architecture and functions of a multipartite genome of the methylotrophic
RT bacterium Paracoccus aminophilus JCM 7686, containing primary and secondary
RT chromids.";
RL BMC Genomics 15:124-124(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
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DR EMBL; CP006652; AGT10808.1; -; Genomic_DNA.
DR RefSeq; WP_020952293.1; NC_022049.1.
DR AlphaFoldDB; S5YH64; -.
DR KEGG; pami:JCM7686_pAMI4p117; -.
DR PATRIC; fig|1367847.3.peg.3746; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_0_2_5; -.
DR OrthoDB; 7805940at2; -.
DR Proteomes; UP000015480; Plasmid pAMI4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd13143; MATE_MepA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR045070; MATE_MepA-like.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43549; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR PANTHER; PTHR43549:SF2; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Plasmid {ECO:0000313|EMBL:AGT10808.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 460 AA; 47952 MW; 242204E4773E5338 CRC64;
MSEGQSPQNR FLQAPPAKIF AQTAVPMILI MLMNGMLHVV DAAFLGHFVG AEAMSAIGVV
FPLTMILIAL STLVSGGMSS LMARQLGAGA QDAAETTFAR AHGLALTIAA VLIALQLLFG
HSMINALSGG DPVIARMAYA FLTIVVLTTP VQFLLGIHAD TCRNEGRAGM MAMMSLGVTL
ANIALNYLFI AVFDWGVAGS AMGSTVAQIF GLSLLVFLRE RAGTRLPITA LGRHSWRGGW
KTIAGLGAPL SLSFIGVALS AFSAILAIRL TAGAAYAETV AAYGLVTRLM GFVFLPMMAM
ALATQSIVGN NAGAGQMDRV RQVLRIALGT ALVYSLAVQI VFFLTGESLG RAFVDDPAVV
AMVGTIIRPM TGFYLFTGPV LVLALYFQAL GKPAQAALLT LVKPYLLVPA GIALAASQWG
TTGIWYIYPV VDAVIAVIAG LVFSANSRSA APATLQGAQP
//
