ID S5YIL9_PARAH Unreviewed; 298 AA.
AC S5YIL9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Formyltetrahydrofolate deformylase {ECO:0000256|HAMAP-Rule:MF_01927};
DE EC=3.5.1.10 {ECO:0000256|HAMAP-Rule:MF_01927};
DE AltName: Full=Formyl-FH(4) hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
GN Name=purU {ECO:0000256|HAMAP-Rule:MF_01927};
GN ORFNames=JCM7686_pAMI5p257 {ECO:0000313|EMBL:AGT11323.1};
OS Paracoccus aminophilus JCM 7686.
OG Plasmid pAMI5 {ECO:0000313|EMBL:AGT11323.1,
OG ECO:0000313|Proteomes:UP000015480}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=1367847 {ECO:0000313|EMBL:AGT11323.1, ECO:0000313|Proteomes:UP000015480};
RN [1] {ECO:0000313|EMBL:AGT11323.1, ECO:0000313|Proteomes:UP000015480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 7686 {ECO:0000313|EMBL:AGT11323.1};
RC PLASMID=Plasmid pAMI5 {ECO:0000313|Proteomes:UP000015480};
RX PubMed=24517536; DOI=10.1186/1471-2164-15-124;
RA Dziewit L., Czarnecki J., Wibberg D., Radlinska M., Mrozek P., Szymczak M.,
RA Schluter A., Puhler A., Bartosik D.;
RT "Architecture and functions of a multipartite genome of the methylotrophic
RT bacterium Paracoccus aminophilus JCM 7686, containing primary and secondary
RT chromids.";
RL BMC Genomics 15:124-124(2014).
CC -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC (formyl-FH4) to formate and tetrahydrofolate (FH4). {ECO:0000256|HAMAP-
CC Rule:MF_01927}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC ChEBI:CHEBI:57453, ChEBI:CHEBI:195366; EC=3.5.1.10;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01927};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_01927}.
CC -!- SIMILARITY: Belongs to the PurU family. {ECO:0000256|HAMAP-
CC Rule:MF_01927}.
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DR EMBL; CP006653; AGT11323.1; -; Genomic_DNA.
DR RefSeq; WP_020953094.1; NC_022043.1.
DR AlphaFoldDB; S5YIL9; -.
DR KEGG; pami:JCM7686_pAMI5p257; -.
DR PATRIC; fig|1367847.3.peg.4291; -.
DR HOGENOM; CLU_038395_3_0_5; -.
DR OrthoDB; 9806170at2; -.
DR UniPathway; UPA00074; UER00170.
DR Proteomes; UP000015480; Plasmid pAMI5.
DR GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04875; ACT_F4HF-DF; 1.
DR CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_C; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR HAMAP; MF_01927; PurU; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR004810; PurU.
DR InterPro; IPR044074; PurU_ACT.
DR NCBIfam; TIGR00655; PurU; 1.
DR PANTHER; PTHR42706; FORMYLTETRAHYDROFOLATE DEFORMYLASE; 1.
DR PANTHER; PTHR42706:SF1; FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR PIRSF; PIRSF036480; FormyFH4_hydr; 1.
DR PRINTS; PR01575; FFH4HYDRLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01927};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW Rule:MF_01927}; Plasmid {ECO:0000313|EMBL:AGT11323.1};
KW Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01927};
KW Reference proteome {ECO:0000313|Proteomes:UP000015480}.
FT DOMAIN 10..66
FT /note="ACT"
FT /evidence="ECO:0000259|Pfam:PF01842"
FT DOMAIN 91..267
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
FT ACT_SITE 230
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01927"
SQ SEQUENCE 298 AA; 33308 MW; 380B8CE8DE563C7E CRC64;
MTTETKQFAL RVACPSIRGV TADIAGFLAA NGCNIRDSAQ FDDENTGRYF MRVSFRSEEG
RTLEDLDAAF APLVAQYGME HEFFDEAAKR KVVLMVSRFG HCLNDLLYRW RIGALPIDIV
AVISNHLDYQ KVVVNHDIPF HHINVTKANK PEAEALQMRV VEESGADLIV LARYMQVLSD
EMCRKMSGRI INIHHSFLPS FKGANPYKQA YERGVKLIGA TSHYVTADLD EGPIIEQDTV
RITHAQSGED YVSLGRDVES QVLARAIHAH VHGRVFINGN KTIVFPASPN SFASERMG
//