UniProt: S6ALD6

Database: UniProt
Entry: S6ALD6_PSERE

LinkDB:  S6ALD6_PSERE 
Original site:  S6ALD6_PSERE

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (8)   
   Pfam (3)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   S6ALD6_PSERE            Unreviewed;       436 AA.
AC   S6ALD6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=GDP-mannose 6-dehydrogenase {ECO:0000256|ARBA:ARBA00020994, ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.132 {ECO:0000256|ARBA:ARBA00012932, ECO:0000256|PIRNR:PIRNR000124};
GN   Name=algD {ECO:0000313|EMBL:BAN49555.1};
GN   ORFNames=PCA10_38230 {ECO:0000313|EMBL:BAN49555.1};
OS   Pseudomonas resinovorans NBRC 106553.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1245471 {ECO:0000313|EMBL:BAN49555.1, ECO:0000313|Proteomes:UP000015503};
RN   [1] {ECO:0000313|EMBL:BAN49555.1, ECO:0000313|Proteomes:UP000015503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 106553 {ECO:0000313|EMBL:BAN49555.1,
RC   ECO:0000313|Proteomes:UP000015503};
RX   PubMed=23887915; DOI=10.1128/genomeA.00488-13;
RA   Shintani M., Hosoyama A., Ohji S., Tsuchikane K., Takarada H., Yamazoe A.,
RA   Fujita N., Nojiri H.;
RT   "Complete Genome Sequence of the Carbazole Degrader Pseudomonas
RT   resinovorans Strain CA10 (NBRC 106553).";
RL   Genome Announc. 1:e00488-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate
CC         + 3 H(+) + 2 NADH; Xref=Rhea:RHEA:21728, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:84886; EC=1.1.1.132;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- PATHWAY: Glycan biosynthesis; alginate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005182, ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00006601, ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; AP013068; BAN49555.1; -; Genomic_DNA.
DR   RefSeq; WP_016493692.1; NC_021499.1.
DR   AlphaFoldDB; S6ALD6; -.
DR   STRING; 1245471.PCA10_38230; -.
DR   KEGG; pre:PCA10_38230; -.
DR   PATRIC; fig|1245471.3.peg.3864; -.
DR   eggNOG; COG1004; Bacteria.
DR   HOGENOM; CLU_023810_1_1_6; -.
DR   OrthoDB; 9803238at2; -.
DR   UniPathway; UPA00286; -.
DR   Proteomes; UP000015503; Chromosome.
DR   GO; GO:0047919; F:GDP-mannose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR028358; GDPman_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR   PANTHER; PTHR43750:SF1; GDP-MANNOSE 6-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43750; UDP-GLUCOSE 6-DEHYDROGENASE TUAD; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500135; GDPman_DH; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE   3: Inferred from homology;
KW   Alginate biosynthesis {ECO:0000256|ARBA:ARBA00022841,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR000124};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015503}.
FT   DOMAIN          317..425
FT                   /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00984"
FT   ACT_SITE        268
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-1"
FT   BINDING         10
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         35
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         86
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         124
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         161
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         210
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         214
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         217
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         225
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         256
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         257
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         259
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         262
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         265
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         271
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
FT   BINDING         324
FT                   /ligand="GDP-alpha-D-mannuronate"
FT                   /ligand_id="ChEBI:CHEBI:84886"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-2"
FT   BINDING         331
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between homodimeric partners"
FT                   /note="in chain A"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR500135-3"
SQ   SEQUENCE   436 AA;  47465 MW;  19D8BCCD1C9CD957 CRC64;
     MRISIFGLGY VGAVCAGCLS ARGHDIVGVD IAAVKIDMIN QGKSPIVEPG LEELLQQGVA
     SGRLRGTLDV REAVLATDIS FIAAPTPSKK NGDLDVSYIA QVCEQISSVL PEKGSRHTVV
     VRSTVLPGTV MNVVVPMLER CSGMKAGIDF GVAVNPEFLR ESTAIKDYDY PAMTVIGELD
     QTSGDLLQAI YQELDAPIIR KGIEVAEMIK YTCNVWHATK VTFANEIGNI AKAVGVDGRE
     VMEVICQDHK LNLSKYYMRP GFAFGGSCLP KDVRALTYRA GQLDIEHPLL HSIMRSNRVQ
     VERAFDLIAS HDKRRIGLLG LSFKAGTDDL RESPLVELAE MLIGKGFDLH IFDRNVEYAR
     VHGANKDYIE SKIPHVSSLL RSDLDEVVAR ADVIVLGNGD PHFASLVEKV APGKTVVDLV
     GFMKERSCAG MEGICW
//

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