ID   S7MED5_MYOBR            Unreviewed;       790 AA.
AC   S7MED5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=FERM domain-containing protein 4B {ECO:0000313|EMBL:EPQ02046.1};
GN   ORFNames=D623_10007540 {ECO:0000313|EMBL:EPQ02046.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02046.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
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DR   EMBL; KE161148; EPQ02046.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MED5; -.
DR   eggNOG; KOG3529; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR021774; CUPID.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR047176; FRMD4A/B.
DR   InterPro; IPR041785; FRMD4A/B_FERM_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR46079:SF1; FERM DOMAIN-CONTAINING PROTEIN 4B; 1.
DR   Pfam; PF11819; CUPID; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          1..265
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          464..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          659..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..545
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        601..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  88507 MW;  697DA9E4C9244518 CRC64;
     MFLSFVSASK TRGQQNWLQL DHRVLDHDLP KKPGPAILHF AVRFYIESIS FLKDRTTVEL
     FFLNAKSCVH KGQIEVDSET VFRLAALALQ EAKGDYTSDE NARKDLRTLS AFPTRTLQEH
     PSLAYCEDRV IEHYLKTRGL TRGQAVVQYM KIVEALPTYG VHYYAVKDKQ GLPWWLGISY
     KGIGQYDLQD KVKPRKLFQW KQLENLYFRE KKFAVEVHDP RRISVSRRTF GQSGLFVQTW
     YAHSSLIKSI WVMAISQHQF YLDRKQSKAK IPSARSLDDI AMDLTEMGTP RTSKPVTLEA
     KSQFIMASNG SLISSGSQDS ELSEEQKREK ILELKKKEKL LQEKLLKKVE ELKKICLREA
     ELTGKMPKEY PLGIGEKPPQ VRRRVGTAFK LDDNLLPSEE DPALQELESN FLIQQKLVEA
     AKKLANEPDL CKTVKKKRKQ DFTDAVRRLQ EIENAINEYR IRCGKKPTQK GTGPLPALVG
     TTNTESTRGV SNHQSSFTRT LPLSNNSEDV IPSESSSLSD TTTCDDPNDT FTLAGQRSSS
     VPHSPRILPP KSLGIERIHF RKSSIGDQLV DARQPREMLS THSSPYKTPE RRPPGGRSMP
     TTPVLTRNAY SSSHLEPEPP AQHCRQRSGS LESQSRLLSE LDHDRPFFSL CKSQRSSSTE
     VLDDGSSCTS QSSADVDSDR GSQRCLGWAA LQVPCSPGSR ASSYSSVSST NVSGSWRTQM
     TVGLSEYEAP AHPSYTSCYG NFYSPLPSPG RQYAEAVALD SADGGRLAGG LEAAEQGLLW
     HEDSKPGTLV
//