ID S7MFT1_MYOBR Unreviewed; 1692 AA.
AC S7MFT1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=D623_10031063 {ECO:0000313|EMBL:EPQ02934.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02934.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE161298; EPQ02934.1; -; Genomic_DNA.
DR eggNOG; KOG0985; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF7; CLATHRIN HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 348..371
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1692 AA; 193482 MW; 0326C741EF209425 CRC64;
MSDKQMGARE HSSGQRIRKL RGYLREMANS PLQNLGINPA NIGFSTLTME SDKFICIREK
VGEQAQVVII DMNDPSNPIR RPISADSAIM NPASKVIALK AGKTLQIFNI EMKSKMKAHT
MTDDVTFWKW ISLNTVALVT DNAVYHWSME GESQPVKMFD RHSSLAGCQI INYRTDAKQK
WLLLTGISAQ QNRVVGAMQL YSVDRKVSQP IEGHAASFAQ FKMEGNAEES TLFCFAVRGQ
AGGKLHIIEV GTPPTGNQPF PKKAVDVFFP PEAQNDFPVA MQISEKHDVV FLITKYGYIH
LYDLETGTCI YMNRISGETI FVTAPHEATA GIIGVNRKGQ VLSVCVEEEN IIPYITNVLQ
NPDLALRMAV RNNLAGAEEL FARKFNALFA QGNYSEAAKV AANAPKGILR TPDTIRRFQS
VPAQPGQTSP LLQYFGILLD QGQLNKYESL ELCRPVLQQG RKQLLEKWLK EDKLECSEEL
GDLVKSVDPT LALSVYLRAN VPNKVIQCFA ETGQVQKIVL YAKKVGYTPD WIFLLRNVMR
ISPDQGQQFA QMLVQDEEPL ADITQIVDVF MEYNLIQQCT AFLLDALKNN RPSEGPLQTR
LLEMNLMHAP QVADAILGNQ MFTHYDRAHI AQLCEKAGLL QRALEHFTDL YDIKRAVVHT
HLLNPEWLVN YFGSLSVEDS LECLRAMLSA NIRQNLQICV QVASKYHEQL STQSLIELFE
SFKSFEGLFY FLGSIVNFSQ DPDVHFKYIQ AACKTGQIKE VERICRESNC YDPERVKNFL
KEAKLTDQLP LIIVCDRFDF VHDLVLYLYR NNLQKYIEIY VQKVNPSRLP VVIGGLLDVD
CSEDVIKNLI LVVRGQFSTD ELVAEVEKRN RLKLLLPWLE ARIHEGCEEP ATHNALAKIY
IDSNNNPERF LRENPYYDSR VVGKYCEKRD PHLACVAYER GQCDLELINV CNENSLFKSL
SRYLVRRKDP ELWGSVLLES NPYRRPLIDQ VVQTALSETQ DPEEVSVTVK AFMTADLPNE
LIELLEKIVL DNSVFSEHRN LQNLLILTAI KADRTRVMEY INRLDNYDAP DIANIAISNE
LFEEAFAIFR KFDVNTSAVQ VLIEHIGNLD RAYEFAERCN EPAVWSQLAK AQLQKGMVKE
AIDSYIKADD PSSYMEVVQA ANTSGNWEEL VKYLQMARKK ARESYVETEL IFALAKTNRL
AELEEFINGP NNAHIQQVGD RCYDEKMYDA AKLLYNNVSN FGRLASTLVH LGEYQAAVDG
ARKANSTRTW KEVCFACVDG KEFRLAQMCG LHIVVHADEL EELINYYQDR GYFEELITML
EAALGLERAH MGMFTELAIL YSKFKPQKMR EHLELFWSRV NIPKVLRAAE QAHLWAELVF
LYDKYEEYDN AIITMMNHPT DAWKEGQFKD IITKVANVEL YYRAIQFYLE FKPLLLNDLL
MVLSPRLDHT RAVNYFSKVK QLPLVKPYLR SVQNHNNKSV NESLNNLFIT EEDYQALRTS
IDAYDNFDNI SLAQRLEKHE LIEFRRIAAY LFKGNNRWKQ SVELCKKDSL YKDAMQYASE
SKDTELAEEL LQWFLQEEKR ECFGACLFTC YDLLRPDVVL ETAWRHNIMD FAMPYFIQVM
KEYLTKVDKL DASESLRKEE EQATETQPIV YGQPQLMLTA GPSVAVPPQA PFGYGYTAPP
YGQPQPGFGY SM
//
