ID   S7MG21_MYOBR            Unreviewed;       609 AA.
AC   S7MG21;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   08-NOV-2023, entry version 37.
DE   SubName: Full=ETS translocation variant 5 {ECO:0000313|EMBL:EPQ02841.1};
GN   ORFNames=D623_10014999 {ECO:0000313|EMBL:EPQ02841.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02841.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   EMBL; KE161269; EPQ02841.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MG21; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR006715; ETS_PEA3_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF160; ETS TRANSLOCATION VARIANT 5; 1.
DR   Pfam; PF00178; Ets; 2.
DR   Pfam; PF04621; ETS_PEA3_N; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 2.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          405..442
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   DOMAIN          503..547
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          168..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..229
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  68608 MW;  AAF84CEDA4A18CA1 CRC64;
     MPLNSVLEDP LSPQKLLNAE TFQSDIRDVG STMDGFYDQQ VPFMVPGKSR SEECRGRPVT
     DRKRKFLDTD LAHDSEELFQ DLSQLQEAWL AEGKFLGSQV PDDEQFVPDF QSDNLVLHAP
     PPTKIKRELH SPSSELSSCS HEQALGANYG EKCLYNYCAY DRKPPSGFKP LTPPTTPLSP
     THQNSLFPPP QATLPTSVHP AAAGPVQGVG PAPTPHSLPD PGPQQQTFAV PRPPHQPLQM
     PKMMPENQYP SEQRFQRQLS EPCHPFPPQS GVPGDNRPSY HRQMSEPIVP AAPPPPQGFK
     QEYHDPLYEH GVPGMPGPPA HGFQSPMGIK QEPRDYCVDS EVPNCQSTYM RGGYFSNSHE
     GFSYEKDPRL YFDDTCVVPE RLEGKVKQEP TMYREGPPYQ RRGSLQLWQF LVTLLDDPAN
     AHFIAWTGRG MEFKLIEPEE FSIEACTVLN MLFSFRSGLV SGLGGALPII QRHSMNPECS
     RLFTQDGSVP SLRFTSGQAA FVVARRWGIQ KNRPAMNYDK LSRSLRYYYE KGIMQKVAGE
     RYVYKFVCDP DALFSMAFPD NQRPFLKAES ECHLNEEDTL PLTHFEDNPA YLLDMDRCSS
     LPYAEGFAY
//