ID S7MHP3_MYOBR Unreviewed; 485 AA.
AC S7MHP3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Growth factor receptor-bound protein 14 {ECO:0000313|EMBL:EPQ03446.1};
GN ORFNames=D623_10035585 {ECO:0000313|EMBL:EPQ03446.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03446.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR EMBL; KE161360; EPQ03446.1; -; Genomic_DNA.
DR AlphaFoldDB; S7MHP3; -.
DR eggNOG; KOG3751; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd10414; SH2_Grb14; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR035034; Grb14_SH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF22; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:EPQ03446.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 19..105
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 179..287
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 384..480
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 485 AA; 55513 MW; E4F70379FE20D15A CRC64;
MSMSGRRVTL PAITPLVLQK RVIKIYSEDE TSRALEVPSD ITARDVCQLL ILKCHYVDDH
CWTLFEHLTL LGLERIIEDH ELVVEVLSNW GMEEENKLYF RKNYAKYEFF KNPMYFFPEH
MVSFSTETNG EISPALILQM PHQNIRVNGS SSTQHLNSQP LQGLTSGIDR VMFLSSSTYP
EIHGFLHAKE QGKKSWKKTY FLLRRSGLYF STKGTSKEPR HLQFFSEFGN SDIYVSLAGK
KKHGAPANYG FCFKPNKARG PRDLKMLCAE EEQSRMCWVT AIRLLKYGMQ LYQNYVHPYH
GRGGCSSQSI SPMRSISENS LVAMDFSGQK SRVIDNPTEA LSVAVEEGLA WRKKACLRLG
NHGSPKASSQ SSAINMVIHR SQPWFHHRIS RDEAQRLIIQ QGLVDGVFLV RDSQSNPRTF
VLSMSHAQKI KHFQILPVED DGQMFHTLDD GHTRFTDLIQ LVEFYQLNKG VLPCKLKHYC
AKIAL
//