ID S7MQI8_MYOBR Unreviewed; 825 AA.
AC S7MQI8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=D623_10030831 {ECO:0000313|EMBL:EPQ06614.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06614.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KE162024; EPQ06614.1; -; Genomic_DNA.
DR RefSeq; XP_005864406.1; XM_005864344.2.
DR RefSeq; XP_014393598.1; XM_014538112.1.
DR AlphaFoldDB; S7MQI8; -.
DR GeneID; 102257182; -.
DR KEGG; myb:102257182; -.
DR CTD; 10312; -.
DR eggNOG; KOG2189; Eukaryota.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 398..423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 444..461
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 504..527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 635..655
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 761..786
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 136..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..277
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 138..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92308 MW; 71377A1E68734672 CRC64;
MGSMFRSEEV SLAQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
LEKTFTFLQE EVRRAGLALP PPEGGLPAPP PRDLLRIQEE SDRLAQELRD VRGNEQALRA
QLHKLQLHAA VLGQGQGPSL AATPTDGSSE RTPLLQPPKG PHQDLRVNFV AGAVEPHKAA
ALERLLWRAC RGFLIASFRE TEQQLEDPVT GEPATWMTFL ISYWGEQIGQ KIRKITDCFH
CHVFPFEEQE EARRGALQQL QQQSQELREV LGETERFLNQ VLGRVQRLLP PWQVQIRKMK
AVYLALNQCS VSATYKCLIA EAWCATRDLP AVQQALHDSS SEAGVSAVVH RIPCRDMPPT
LIRTTRFTAS FQAIVDAYGV GRYQEVNPAP YTIITFPFLF AVMFGDVGHG LLMFLFALAM
VLAEDRPAIK TAKNEIWQTF FGGRYLLLLM GLFSVYTGFI YNECFSRATV IFPSGWSVAA
MANQSGWSDK FLANHPLLSL DPNITGVFLG PYPFGIDPIW SLAVNHLTFL NSFKMKMSVI
LGVTHMAFGV VLGVFNHIHF GQWHRLVLET LPELVFLLGL FGYLVFMVIY KWLRVSAAGA
ASAPSILIHF INMFLFSRSP TNRPLFPGQE VVQSALVVLA LATVPVLLLG TPLFLRWNHH
RHLRRAGQLQ DEVKTGLLDS PDARGSDEEK AEHPGDQEEA KFVLSEVFMH QAIHTIEFCL
GCISNTASYL RLWALSLAHA QLSEVLWAMV MRIGLGMGRE MGVVALVLVP VFAAFAVLTV
AILLVMEGLS AFLHALRLHW VEFQNKFYSG TGYKLNPFTF SMEDQ
//