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Database: UniProt
Entry: S7MQI8_MYOBR
LinkDB: S7MQI8_MYOBR
Original site: S7MQI8_MYOBR 
ID   S7MQI8_MYOBR            Unreviewed;       825 AA.
AC   S7MQI8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   25-APR-2018, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=D623_10030831 {ECO:0000313|EMBL:EPQ06614.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06614.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D.,
RA   Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N.,
RA   Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A.,
RA   Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KE162024; EPQ06614.1; -; Genomic_DNA.
DR   RefSeq; XP_005864406.1; XM_005864344.2.
DR   RefSeq; XP_014393598.1; XM_014538112.1.
DR   GeneID; 102257182; -.
DR   KEGG; myb:102257182; -.
DR   CTD; 10312; -.
DR   KO; K02154; -.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000052978};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    398    423       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    444    461       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    504    527       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    558       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    570    590       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    597    615       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    635    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    786       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    114       {ECO:0000256|SAM:Coils}.
FT   COILED      246    277       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   825 AA;  92308 MW;  71377A1E68734672 CRC64;
     MGSMFRSEEV SLAQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVRRAGLALP PPEGGLPAPP PRDLLRIQEE SDRLAQELRD VRGNEQALRA
     QLHKLQLHAA VLGQGQGPSL AATPTDGSSE RTPLLQPPKG PHQDLRVNFV AGAVEPHKAA
     ALERLLWRAC RGFLIASFRE TEQQLEDPVT GEPATWMTFL ISYWGEQIGQ KIRKITDCFH
     CHVFPFEEQE EARRGALQQL QQQSQELREV LGETERFLNQ VLGRVQRLLP PWQVQIRKMK
     AVYLALNQCS VSATYKCLIA EAWCATRDLP AVQQALHDSS SEAGVSAVVH RIPCRDMPPT
     LIRTTRFTAS FQAIVDAYGV GRYQEVNPAP YTIITFPFLF AVMFGDVGHG LLMFLFALAM
     VLAEDRPAIK TAKNEIWQTF FGGRYLLLLM GLFSVYTGFI YNECFSRATV IFPSGWSVAA
     MANQSGWSDK FLANHPLLSL DPNITGVFLG PYPFGIDPIW SLAVNHLTFL NSFKMKMSVI
     LGVTHMAFGV VLGVFNHIHF GQWHRLVLET LPELVFLLGL FGYLVFMVIY KWLRVSAAGA
     ASAPSILIHF INMFLFSRSP TNRPLFPGQE VVQSALVVLA LATVPVLLLG TPLFLRWNHH
     RHLRRAGQLQ DEVKTGLLDS PDARGSDEEK AEHPGDQEEA KFVLSEVFMH QAIHTIEFCL
     GCISNTASYL RLWALSLAHA QLSEVLWAMV MRIGLGMGRE MGVVALVLVP VFAAFAVLTV
     AILLVMEGLS AFLHALRLHW VEFQNKFYSG TGYKLNPFTF SMEDQ
//
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