GenomeNet

Database: UniProt
Entry: S7MRV3_MYOBR
LinkDB: S7MRV3_MYOBR
Original site: S7MRV3_MYOBR 
ID   S7MRV3_MYOBR            Unreviewed;       479 AA.
AC   S7MRV3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Iroquois-class homeodomain protein IRX-6 {ECO:0000313|EMBL:EPQ07181.1};
GN   ORFNames=D623_10004756 {ECO:0000313|EMBL:EPQ07181.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ07181.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC       {ECO:0000256|ARBA:ARBA00008446}.
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DR   EMBL; KE162138; EPQ07181.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MRV3; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR   PANTHER; PTHR11211:SF11; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-6; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          145..208
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        147..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          209..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          460..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..277
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  51506 MW;  6EC7891FB5D34690 CRC64;
     MAFPHFGHPY GSASQFLVSA NSSATCCESS PSSVPDVASG STPPAALCLA PYDSRLLGSA
     RPELGTALGI YGAPYAAAAA AQSYPGYLPY SPEPPALYGA LNAQYEFKET AGTFTPSLSQ
     PGAYCPYEPT LGQYPYDRYG SAVELTGAGR RKNATRETTS TLKAWLHEHR KNPYPTKGEK
     IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPKNKGG EERKAEDGAQ ESLDCLHAGD
     TKDLAASREV RGFRLSDPED PEEEEGEEEE EEEIEEEAAV PAMDRLAEFH HDAQARATSG
     DADFLRAEPG APTLTTHYPC SQKPRIWSLA HTATASAVQG APPTPPKPRS PECCLILQQP
     AGPGGRPQVL RDSARDEPGR VAKAFGKPTF AMQGLPLSCA PCPRLREPAG QCQYPSGAEG
     SGPPMALGLC PKDACPCAAQ PWHALSDPWA RPGSTWHEMV PQHSLKRKLR DSGSSVPSF
//
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