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Database: UniProt
Entry: S7MST5_MYOBR
LinkDB: S7MST5_MYOBR
Original site: S7MST5_MYOBR 
ID   S7MST5_MYOBR            Unreviewed;       873 AA.
AC   S7MST5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN   ORFNames=D623_10033309 {ECO:0000313|EMBL:EPQ06365.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06365.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   EMBL; KE162005; EPQ06365.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MST5; -.
DR   eggNOG; KOG1480; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd08801; Death_UNC5D; 1.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR042058; UNC5D_Death.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   TRANSMEM        300..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          86..164
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          462..602
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   873 AA;  97528 MW;  C75212355DAC57B5 CRC64;
     MQIFFKCNGE WVHQNEHVSE ESLDESSGLK VREVFINVTR QQVEDFHGPE DYWCQCVAWS
     HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC RPPEGVPAAE VEWLKNEEPI
     DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR RSLSATVVVY VNGGWSSWTE
     WSACNVRCGR GWQKRSRTCT NPAPLNGGAF CEGMSVQKIT CTSLCPVDGS WEVWSEWSVC
     SPECEHLRIR ECTAPPPRNG GKFCEGLSQE SENCTDGLCI LDKKPLHEIK PQSIENASDI
     ALYSGLGAAV VAVAVLVIGV TLYRRSQSDY GVDVIDSSAL TGGFQTFNFK TVRQGNSLLL
     NSSMQPDLTV SRTYSGPICL QDPLDKELMT ESSLFNPLSD IKVKVQSSFM VSLGVSERAE
     YHGKNHSGTF PHGNNRSFST VHPRNKTPYL QNLSSLPTRT ELRTTGVFGH LGGRLVMPNT
     GVSLLIPHGA IPEENSWEIY MSINQGEPSL QSDGSEVLLS PEVTCGPPDM IVTTPFALTI
     PHCADVSSEH WNIHLKKRTQ QGTWEEVMSV EDESTSCYCL LDPFACHVLL DSFGTYALTG
     EPITDCAVKQ LKVAVFGCMS CNSLDYNLRV YCVDNTPCAF QEVVSDERHQ GGQLLEEPKL
     LHFKGNTFSL QISVLDIPPF LWRIKPFTAC QEVPFSRVWC SNRQPLHCAF SLERYTPTTT
     QLSCKICIRQ LKGHEQILQV QTSILESERE TITFFAQEDS TFPAQTGPRA FKIPYSIRQR
     ICATFDTPNA KGKDWQMLAQ KNSINRNLSY FATQSSPSAV ILNLWEARHQ HDGDLDSLAC
     ALEEIGRTHT KLSNITESQL DEADFNYSRQ NGL
//
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