ID S7MUD7_MYOBR Unreviewed; 409 AA.
AC S7MUD7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
GN ORFNames=D623_10021665 {ECO:0000313|EMBL:EPQ06970.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06970.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
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DR EMBL; KE162084; EPQ06970.1; -; Genomic_DNA.
DR AlphaFoldDB; S7MUD7; -.
DR eggNOG; KOG1660; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07662; BAR_SNX6; 1.
DR CDD; cd07292; PX_SNX6; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR028657; BAR_SNX6.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042136; PX_SNX6.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45850:SF4; SORTING NEXIN-6; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT DOMAIN 29..176
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 409 AA; 47197 MW; C2058745E9C7F5DF CRC64;
MKIEKHYHEL ESTYNAMMNM DLKAINVDLQ SDAALQVDIS DALSERDKVK FTVHTKSSLP
NFKQNEFSVV RQHEEFIWLH DSFVENEDYA GYIIPPAPPR PDFDASREKL QKLGEGEGSM
TKEEFTKMKQ ELEAEYLAIF KKTVAMHEVF LCRVAAHPIL RKDLNFHVFL EYNQDLSVRG
KNKKEKLEDF FKNMVKSADG VIVSGVKDVD DFFEHERTFL LEYHNRVKDA SAKSDRMTRS
HKSAADDYNR IGSSLYALGT QDSTDICKFF LKVSELFDKT RKIEARVSAD EDLKLSDLLT
YYLRESQAAK DLLYRRSRSL VDYENANKAL DKARAKNKDV LQAETSQQLC CQKFEKISES
AKQELIDFKT RRVAAFRKNL VELAELELKH AKGNLQLLQN CLAVLNGDT
//
