ID S7MVH5_MYOBR Unreviewed; 1388 AA.
AC S7MVH5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Histone-lysine N-methyltransferase SETDB1 {ECO:0000313|EMBL:EPQ08494.1};
GN ORFNames=D623_10031834 {ECO:0000313|EMBL:EPQ08494.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ08494.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KE162497; EPQ08494.1; -; Genomic_DNA.
DR eggNOG; KOG1141; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10517; SET_SETDB1; 1.
DR CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040880; DUF5604.
DR InterPro; IPR025796; Hist-Lys_N-MeTrfase_SETDB1.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF18300; DUF5604; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS51573; SAM_MT43_SUVAR39_1; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000313|EMBL:EPQ08494.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EPQ08494.1}.
FT DOMAIN 691..762
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 824..897
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 900..1363
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1372..1388
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 124..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..80
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 136..151
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..512
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1007
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1388 AA; 152453 MW; C4838BA2B02B3026 CRC64;
MAPVRLRGRP LSQDHSMSSL PGCLGLDAEA AAMESEEIAE LQQAVVEELG ISMEELREFI
DKELEKMDCI QQRRKQLAEL ETWVIQKETE VAHVDQLFDD ASRAVTNCES LVKDFYSKLG
LQYRDSSSED EASQPTEIIE IPDEDDDVLS IDSGDAGSRT PKDQKLREAM AALRKSAQDV
QKFMDAVNKK SSSQDPHKGA LSQMSGELSK DGDLIVSMRI LGKKRTKTWH KGTLIAIQTV
GPGKKYKVKF DNKGKSLLSG NHIAYDYHPP ADKLYVGSRV VAKYKDGNQV WLYAGIVAET
PNVKNKLRFL IFFDDGYASY VTQSELYPIC RPLKKTWEDI EDISCRDFIE EYITAYPNRP
MVLLKSGQLI KTEWEGTWWK SRVEEVDGSL VRILFLDDKR CEWIYRGSTR LEPMFSMKTS
SASTLEKKQG GQFRTRPNMG AVRSKGPVVQ YTQDLTSTGT QFKPTELPQP TAPPAPSATT
PVPPAPPIPL APPVPPATLT PPAPPAPPLS PPAGDTESLE SQLAQSRKQV AKKSTSFRLG
SVGSGHSSPT SPSLSENAPG GKPGISQTYR SPLGSTASAP APPASPASTV LPALPASTVL
PALPASAVLP VLPASAVLPA STVLPVLPVT TVLPVSTVLP ASTALPAFHG MLERAPAEPS
YRAPMEKLFY LPHVCSYTCL SRVRPIRSEQ YRGKNPLLVP LLYDFRRMTA RRRVNRKMGF
HVIYKTPCGL CLRTMQEIER YLFETGCNFL FLEMFCLDPY VLVDRKFQPY KPFYYILDIT
YGKEDVPLSC VNEIDTTPPP QVAYSKERIP GKGVFINTGP EFLVGCECTD GCRDKSKCAC
HQLTIQATAC TPGGQINPNS GYQNKRLEEC LPTGVYECNK RCKCDPNMCT NRLVQHGLQV
RLQLFKTQNK GWGIRCLDDI AKGSFVCIYA GKILTDDFAD KEGLEMGDEY FANLDHIESV
ENFKEGYESD APCSSDSSGV DLKDQEDGNS GTEDPEESND DSSDDNFCKD EDFSTSSVWR
SYATRRQTRG QKENGLSETA SKDSRPPDLG PPHLPVPLSI SMGSCNPPSS EETSKSKVAS
WLSSNSVSEG GFADSDSRSS FKTSEGGEGR AGGVKGEAEK ASASALSFKD EGDIKQAKKE
EPDDRNKVSI VTESARNYGY NPSPMKTEGL RRPPSKTSMH QSRRLLASAQ SHADDVLTLS
SSTESEGESG TSRKPTAGQT SATAVDSDDI QTISSGSEGD DFEDKKNMSG PMKRQVAVKS
TRGFALKSTH GIAIKSTNMA SAEKGESAPV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN
HSCSPNLFVQ NVFVDTHDLR FPWVAFFASK RIRAGTELTW DYNYEVGSVE GKELLCCCGA
IECRGRLL
//
