ID   S7MXM4_MYOBR            Unreviewed;      1090 AA.
AC   S7MXM4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   ORFNames=D623_10028569 {ECO:0000313|EMBL:EPQ08300.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ08300.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; KE162454; EPQ08300.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MXM4; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          549..820
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          895..1025
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          539..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1090 AA;  118005 MW;  2FF5006A7F9B1D73 CRC64;
     MLETLSFSSF PGPQGGLYPE GWHWRRPHGK TCPGLRESPF IRPRGAPSLP LFSVALWGAL
     LWAGSLPSRA WGVGTFTLGV LGPWDCDLIF AQALPRVAAQ LAVDRANQDS SLMLGSRLAS
     VVLPTGCDTP RALATFLVHQ NTVAAFVGPV NPGYCPAAAL LAQGWGKTLF SWACEAPLGG
     GELVPTLPSA THVLLSVMKH FGWARVAIVS SHQDIWVATA RQVAVTLRTH GLPVVLVASL
     GPGEQGATEV LKQLRGVDGL KVVVLCMHSA LLGGSEQMAL LRQAWAQGLA DGRLVFLPYD
     TMLFALPYRN RSYPALGRGG PLREVYDAVL SVTLESGPVD EVIKAAGASE EGAAHLEPEQ
     VSPLFGTIYD AVVLLAYALN RSGSHGAGLS GAHLGAHTGA LDVAGFSQRI RTDEKGRRLA
     QYVILDTDGQ ESQLVPTHVL DTGTWQVQPL GRAIHFPGGA PPARDSSCWF DPSALCTRGT
     QPPGSFLALA LACVVVLAGG ALTCLIRLGV RQLQLVRGPH RILLTAQELA FIHPPLSSQR
     LHTDRDSASE SRSAADGGSL RSVALGSARS PQEPTNVALY QGEWVRLKTF EAGTAPELRP
     SCLRLLRKMR ELRHENIATC LGFFVAPGVS ALVLEHCARG SLEDLLQNEA LRLDWTFQAS
     LLLDLIRGVR YLHHQHFPHG RLKSRNCVVD ERFVLKVTDH GYAGLLDAGR APRPRPAPED
     LLWTAPELLR GPRGPGRGTL RGDVFSVGII LQEVLTRGPP YGSSGLSAEE IIRKVASPPP
     LCRPLVSPDH GPPECIQLME QCWEEAPEDR PSLDHIYTQF KSINHGKKTS VADSMLRRLE
     KYSQNLEGLI RARTEELELE RQKTERLLSQ MLPLSVAEAL KTGATVEPEY FDHVTIYFSD
     IVGFTTISAL SEPMEVVGLL NDLYTLFDAV LGSHDVYKVE TIGDAYMVAS GLPRRNGSRH
     AAEIANMALD ILSSVGDFRM RHAPDVPICI RAGLHSGPCV AGVVGLTMPR YCLFGDTVNT
     ASRMESTGLP YRIHVSRSTV QTLLSLDEGY KIDIRGQTEL KGKGVEETYW LTGKAGFPRP
     LPTPLDIKPE
//