ID   S7MZR0_MYOBR            Unreviewed;      3559 AA.
AC   S7MZR0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Dynein heavy chain 12, axonemal {ECO:0000313|EMBL:EPQ09090.1};
GN   ORFNames=D623_10027623 {ECO:0000313|EMBL:EPQ09090.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09090.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; KE162632; EPQ09090.1; -; Genomic_DNA.
DR   eggNOG; KOG3595; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 2.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          1133..1272
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          1637..1785
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          216..294
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          464..527
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2486..2548
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   3559 AA;  409309 MW;  9994754CA98D1394 CRC64;
     MLNAGAAMMH TSHLQRNGTM DLAPTKQHSA SPKWDTGPAT TLFNSPPNCS QCCQDAMPQN
     VAHSLAQPGN SGCGRRIKDL LKRTVEGFVK LFDQGDERGL PIFKMELTID DEKMEFYPTF
     QDLEDVVFGL VERIAEALQW VHFPMVRLDC EDLKKGLTNK ARAFANKLLN DIATKHRNEN
     ECEFEAIKEH ALKIPETTEE MMDLIAYVEK ARTIRMQDLI SRIQIIEVAK RKKENELIAK
     REKLILELEK ESRRMEEFAE FAELDRMQQY VTDVRQLQKR IQESEEAVQF INKEEELFKW
     EVTKYPELDK LKVNIEPYQK FFNLVLKWQR TEKRWMDGGF LDLNGESMEA DVDEFSREIF
     KTLKFFQMKL KKELQEKRKL AKRRSVGEER VEEEPKENPT INMCSTVMEN IKVFKESKRR
     MNYFLDVFIF PQEDLALNSA VLLWPWKIYP IFDENDEIIE VAKRKKENEL IAKREKLILE
     LEKESRRMEE FAEFAELDRM QQYVTDVRQL QKRIQESEEA VQFINKEEEL FKWEVTKYPE
     LDKLKVNIEP YQKFFNLVLK WQRTEKRWMD GGFLDLNGES MEADVDEFSR EIFKTLKFFQ
     MKLKKELQEK RKLAKRRSVG EERVEEEPKE NPTINMCSTV MENIKVFKEN IPTVSILCNP
     GMRARHWKQM SEIVGYDLTP DSGTTLRKVL KLNLSQYLEQ FEVISAGASK EFSLEKAMHT
     MMGVWDDIAF HVSLYRETGV CILSSVDEIQ ALLDDQIIKT QTMRGSPFIK PFEKEIKAWE
     DRLIRIQETI DEWLKVQAQW LYLEPIFCSE DIMQQMPEEG RQFQTVDRHW RDVMKFCAKD
     PKVLAATSLT GLLEKLQSCN ELLEKIMKGL NAYLEKKRLF FPRFFFLSND EMLEILSETK
     DPLRVQPHLK KCFEGIAKLE FLPNLDIKAM YSSEGERVEL IALISTSAAR GAVEKWLIQV
     EDLMLRSIHD VIAAARLAYP DSTRRDWVRE WPGQVVLCVS QMFWTSETQE VISDGTKGLI
     KYYKELQNQL NDIVGLVRGK LSKQTRTTLG ALVTIDVHAR DVVMDMIDVG VSHNTDFQWL
     AQLRYYWEYE NARVRIINCN VKYAYEYLGN SPRLVITPLT DRCYRTLIGA FYLNLGGAPE
     GPAGTGKTET TKDLAKALAV QCVVFNCSDG LDYLAMGKFF KGLASSGAWA CFDEFNRIEL
     EVLSVVAQQI LCIQRAIQQK LDVFVFEGAE LKLNPNCFVA ITMNPGYAGR SELPDNLKVL
     FRTVAMMVPN YALIAEISLY SYGFLNAKPL SVKIVMTYRL CSEQLSSQFH YDYGMRAVKA
     VLVAAGNLKL KFPNENEDIL EFLECAHEVC KVHNLQPVKF FIEKMIQTYE MMIVRHGFML
     VGEPFAAKTE VLHVLADTLT LMHERGYGEE EKVIYRTVNP KSITMGQLFG QFDPVSHEWT
     DGIVANTFRE FALSETTDRK WVVFDGPIDT LWIESMNTVL DDNKKPATVS RCGMIYLEPS
     QLGWEPLVSS WLSSLKGPLQ EDEHQALLRG LFDWLIWPSL RLRKKQCKEL IPTSDSNAVV
     SLTRLFEVLL CDVVENDPTS KHIHVWIMLK NRGRWVHWNE LIKSTDLGDK RIKIQDIIVP
     TMDTVRYTFL MNLSITYAKP LLFVGPTGTG KSVYVKDKLM NHLEKNKYFP FYVNFSARTS
     ANQVQNIIMA RLDKRRKGVF GPPMGKKCII FIDDMNMPTL EKYGAQPPIE LLRQFFDCGN
     WYDLKDTSKI TLVDIQLIAA MGPPGGGRNP VTPRFIRHFN ICTINAFSDE TMVRIFSSIV
     AFYLRTREFP PEFFLIGNQI VSGTMEIYKQ SMKNLLPTPT KSHYTFNLRD FSRVIQGCLL
     IERDAVGSKH TMIRLFVHEV LRVFYDRLIN DEDRYWLFNL IKVVIKEHFK ESFDSVFSHL
     RKENAPVTEK DLRNLMFGDY MNTDLEGDDR VYIEIPNIHQ FSDIVDQCLD EYNQTHKRRM
     NLVIFRYVLE HLSRICRILK QSGGNALLVG LGGSGRQSLT RLATSMAKMQ IFQPEISKSY
     GMNEWREDMK VLLRNVGMRG HKTVFLITDT QIKEEAFLED IDSVLNTGEV PNIFAADEKQ
     EVMEGVRPVA QAGNKHGELS PLALFAFFVN RCKDNLHVVV AFSPIGDAFR NRLRQFPSLI
     NCCTIDWFQP WPEDALELVA VKFLETLELT EVERREIVPI CKHFHTSIMD LSERFLQELG
     RHNYVTATSY LELIASFRQL LTQKRQAVVE AKQRYVNGLD QLAFAESQVG EMKLELVQLQ
     PKLEEAKIEN AHMMQVIEIE SAQVEAKRKF VKLDEEVASG KAEEAQLLKN ECESDLAEAI
     PALEAALSAL DTLKASPADI TIVKSMKNPP SGVKLVMAAI CVMKDIKPEK ITDPSGTGGK
     IFDYWGPSKK LLGDMNFLRD LKEYDKDNIP VNVMQKIRGD YLTNPEFDPP KIAKASSAAE
     GLCKWIMAME VYDRVAKVVA PKKARLTEAQ KSLAEIMEIL NQKRAELAEV EHHLENLQNI
     FSEKTEEKAR LEDQVELCAK KLERASKLIG GLGGEKSRWS QAADDLQIVY ENLTGDVLVS
     AGVIAYLGAF TSGFRQTCTE NWSMLCKEKK FPCSEEFSLS KTLGDPVKIR AWNIAGLPTD
     TFSIDNGVIV NNSRRWPLMI DPQGQANKWI KNSEKDNQLS VIKLSDSDYM RTLENCIQFG
     TPLLLENVGE ELDPSLEPLL LRQTFKQGGI DCIRLGEVII EYSFDFKFYI TTKLRNPHYM
     PELATKLSLL NFMITPEGLE DQLLGIVVAK ERPELEEERN ALILQSAANK KQLKDIEKRI
     LETLSSSEGN ILEDESAIKV LDSAKMMSNE ITKKQQIAEK TELKIAESRE GYRPIAKHSS
     VLFFSIADLA NIDPMYQYSL SWFVNLYINS IHDRAKKEID YQELMFLLTG GVSLKSAEKN
     PDPTWLQDKS WEEICRASEF PAFQGLRSHF CKYIDEWQKI YDSKEPHNAV LPEPMNQTLN
     ELQKIIILRC LRPDKITPAI TNYVTDKLGK KFVEPPPFDL TKSYWDSNCT IPLIFVLSPG
     ADPMASLLKF ANDKAMTGNK FQAISLGQGQ GPIATKMIKA AIEEGTWAWE KLLFGVCFFH
     ALVQERKKFG PLGWNIPYGF NESDLRISIR QLQLFINEYD TIPFEAISYL TGECNYGGRV
     TDDWDRRLLL TMLADFYNTH IIENPHYKFS PSGNYFAPPR GTYNDYIEFI KKLPFTQHPE
     VFGLHENVDI SKDLQQTKVL FESLLLTQGG SKQTGSSGST DQILFEISRD ILQKLPNDFD
     IEAALLTYPV SYEESMNTVL VQEMERFNNL IKTIRSTLQD LEKAIKGVVV MDSALEALSG
     SLLVGKVPEI WAQRSYPSLK PLGSYITDFL ARLNFLQDWY DSGKPCVFWL SGFFFTQAFL
     TGAMQNYARK YTIPIDLLGY EFEVIPYDKS ETSPEDGVYI HGLYLDGARW DRPSGLLAEQ
     YPKLLFDLMP IIWIKPNQKA QIEKSNAYVC PLYKTSERKG TLSTTGHSTN FVIAMLLKTD
     QPVQHWIKRG VALLCQLDD
//