ID   S7N0W9_MYOBR            Unreviewed;      2072 AA.
AC   S7N0W9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=D623_10011362 {ECO:0000313|EMBL:EPQ09625.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09625.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KE162794; EPQ09625.1; -; Genomic_DNA.
DR   eggNOG; KOG0890; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR012993; UME.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF08064; UME; 1.
DR   SMART; SM00802; UME; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EPQ09625.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transferase {ECO:0000313|EMBL:EPQ09625.1}.
FT   REPEAT          791..825
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          1641..2072
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2072 AA;  235937 MW;  751A4D1E9DB46E09 CRC64;
     MDCGRAPGRI RPISPSPEWP DHSSKLTYWL ERLPPVVALE LVKKTDSQPT SVMLLDFIQH
     IMKSSPLMFV NVNGSHEQNE AKGCCIDFSN WIIRRLLRIA ATPSCHMLHK KICEVICSLL
     FLFKTKSPAI FGVLTKELLH LFEDLIYLHR RNAMGQFVEW PVVLSRFLSQ LDEHVGYLQS
     APLKFTNMQN LEFIEVTLLT VLIRIIAIVF FRRQELLLWQ IGCVLLEYGS PKIKSLSISL
     LTELFELGGL PAQLASTFFS SFLELLKHLV EMDADQLKLY EDPLSKLIKT LFPFEAEAYR
     NIEPVYLNML LEKLCVMFEN GVLMWLKSDL LKGAFCHLLQ YFLKYVPAGY ESALQVRKVY
     VKNICRTLVD VLGIQVDAEY LLGPLYAALK MESMEIIEEV QIQQENLSSK SDGISPKRRR
     LSSSLNSSKR ATKQTEEINH VDMNKKSILW SALKQKAESL QTLLDCSSLK NPVTETLEGI
     AVVLQLTALC TVYCSPQNMD CHNFKDCHQK CKKKTSVVIT WMSLDFYTKV LKSCRSLLEC
     VQKPDLEAVI DKVMKIYDVL IYIQVKTSFE DHILEDLCGM LSLPWIYSHS DDGSLKLTTF
     ATNLLTLSQR TSDSFSPQAQ SRCVFLLTLF PRRIFLEWRI AVYSWALQSS HEVIRTSCVN
     GFFILFQKQN SYHTVPKILI DKVKDDSDIV KKEFASILGQ LVCTLHGMFY LTSSLIEPFS
     EHGHIDFCKS LKVTSQHECL SSRLRASVFK PFLFLLKEKV PSLVKLAFID NLCHLCKHLD
     FREDETDVKT VLGTLLNLME DPDKDVRVAF SGNIKHILES LDSEDGFIKE LFVLRMKEAY
     THAQISRNNE LKDTLILTTG DIGRAAKGDL VPFALLHLLH CLLSKSASVS GAAYTEIRAL
     VAAKSVKLQN FFSQYKKPIC QFLVESLHSS QIAVLPSTPC QNAEMRKQDM AHQREMALNT
     LSEIANVFDF PDLNRFLTRT LQLLLPDLAA KASPAASALI RTLGKQLNVN RREILINNFK
     YIFSHLVCSC SKDELERALH YLKNETEIEL GSLLRQDFQG LHNELLLRIG ENYQQVFNGL
     SILASFASSD DPYQGPRDSI SPELMGETQQ KDKFSVQYIS ADYLQPKLLG ILAFFNMQLL
     SSSVGIEDKK MALNSLVSLM KLMGPKHVSS VRVKMMTTLR TGLRFKDDFP ELCCRAWDCF
     VRCLDHVYLG SLLSHVIVAL LPLIHIQPKE TAAIFHYLII ENRDAVQDFL HEIYFLPDHL
     ELKKIKAVLQ EYRKETSESN DLQTTLQLSM KAIQHENVDV RIHALTSLKE TLYKNQEKLI
     KYATDSETVE PVISQLVTVL LKGCQDANSQ ARLLCGECLG ELGAIDPGRL DFSTTETQGK
     DFTFVTGVED SSFAYGLLME LTRAYLAYAD NSRAQDSAAY AIQELLSIYD CREMPTDSPG
     HQLWRKFPEH VREILEPHLN TRYKSSQKST DWSGVKKPIY LSKLGNNFAE WSASWAGYLI
     TKVRHDLASK IFTCCSIMMK HDFKVTIYLL PHILVYVLLG CNQEDQQEVY AEIMAVLKHD
     DQHTINTQYS ASDLCQLSTQ TVFSMIDHLT QWSRHKFQAL NAEKFPQSKS NRDKVDSIVS
     TVDHEDYQSV TRFLDLIPQD TLAVASFRSK AYTRAVMHFE SFITEKKQDI QEHLGFLQKL
     YAAMHEPDGV AGVSAIRKAE PSLKEQILEH ESIGLLRDAT ACYDRAIQLE PDQIIHYHGV
     VKSMLGLGQL STVITQVNGV HANRSEWTDE LNTYRVEAAW KLSQWDLVEN YLAADGKSTT
     WSVRLGQLLL SVKKRDTTAF YDTLKLVRAE QIVPLSAASF ERGSYQRGYE YIVRLHMLCE
     LEHSIKPLFH ESLGDNSQED SLNWVARLEM TQNSYRAKEP ILALRRALLS LNKRQDYNEM
     VGECWLQSAR VARKAGHHQT AYNALLNAGE SRLAELYVER AKWLWSKGDV HQALIVLQKG
     VELCFPENKT PTESKDMLIH GRAMLLVGRF MEETANFESN AVMKKYKAVW DLLLLTACCS
     LLLDCCSLVL PRRRERLPPP LLRLPGVSPA SG
//