ID   S7N5J8_MYOBR            Unreviewed;       610 AA.
AC   S7N5J8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Aminopeptidase O {ECO:0000313|EMBL:EPQ12374.1};
GN   ORFNames=D623_10015797 {ECO:0000313|EMBL:EPQ12374.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ12374.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
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DR   EMBL; KE163505; EPQ12374.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7N5J8; -.
DR   eggNOG; KOG1047; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR033577; AOPep.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR46627; AMINOPEPTIDASE O; 1.
DR   PANTHER; PTHR46627:SF1; AMINOPEPTIDASE O; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Aminopeptidase {ECO:0000313|EMBL:EPQ12374.1};
KW   Hydrolase {ECO:0000313|EMBL:EPQ12374.1};
KW   Protease {ECO:0000313|EMBL:EPQ12374.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          414..601
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
SQ   SEQUENCE   610 AA;  68073 MW;  694AD763B829E01C CRC64;
     MDIKLDPSRD DLPLMANTSH ILVKHYVLDL DVDFESQIID GTLVLFLESG NRSRKKSGST
     EEACRSESNE ACRFRKPEPC HVPVADTRTS WSQMGYSDFA ICGKGERDTS GKDGNHDNQE
     QTYGISSSKH CCDTGNHGSE DFLLVLDCCD LSVLRVEEVD VAAVPGIEKF TRSPKLTVVS
     ELRNQIVREL VTLPADRWRE QLDYYARCSL APGCGELLFD TDTWSLQIRK TGAQTATAFP
     HAIRIRPCVY TMGSPINNRA LFPCQEPPVA MSTWQATVRA AASFVVLMSG ENSAKPTQLR
     EGCSSWHYYV TMPMPASTFT IAVGPWTEVK PETCSPSDLA AERSLSPSEA DFRCAGVCGH
     MEYPCRFQDP SATTQEIIPH RVFAPESLAG ACQETLLQLL SPCLSAAHAV LGTHPFSRLD
     VLIVPANFPS LGMASPHIVF LSQSTLAGGS HLCGTRLCHE IAHAWFGLAI GARDWTEEWL
     SEGFATHLED VFWAKAQQLA PHEAQEQQEL RASLRWRRLQ DESRNSPEQL QVLRPNKEKT
     GHVSDSGSSV IKHGLNPEKV FMQVHYLKGY FLLRFLARRL GDDTYFSFLR KFVHTFHGQL
     ILSQVIYEYL
//