ID S7N872_MYOBR Unreviewed; 866 AA.
AC S7N872;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:EPQ13409.1};
GN ORFNames=D623_10003049 {ECO:0000313|EMBL:EPQ13409.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13409.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KE163703; EPQ13409.1; -; Genomic_DNA.
DR AlphaFoldDB; S7N872; -.
DR eggNOG; KOG1933; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..866
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004543252"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..361
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 833..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 95629 MW; D3EDE58214F5BD77 CRC64;
MSQTLRNLTC FRICILFQVL DLQTAIEHIT ASYNNETVTL QDICLAPLSP YNKNCTILSV
LNYFQNSHSM LDHEIGDDFY TYADYHTHLL YCVRAPASLN DTSLLHDPCL GTFGGPVFPW
LVLGGYDDQN YNNATALVMT FPVNNYYNDM EKLQRAQAWE REFINFVKNY KNPNLTISFT
AERSIEDELN RESNSDISTV VTSYAVMFLY ISIALGHIQS CSRLLVDSKV SLGIAGIFIV
LSSVACSLGI FSYVGVPLTL IVIEVIPFLV LAVGVDNIFI LVQTYQRDER LEGETLDQQL
GRVLGEVAPS MFLSSFSETV AFFLGALSVM PAVHTFSLFA GMAVLIDFLL QITCFVSLLG
LDVKRQENNR LDILCCVHGG EDGAGLQASE SCLFRFFRDS YSPLLLKAWM RPIVMAVFVG
VLSFSIAVLN KVEIGLDQSL SMPEDSYVMD YFRSLSQFLH AGPPVYFVVE EGLDYTSLQG
QNLVCGGMGC NNDSLVQQLF DAAELDAYTR IGFAPSSWID DYFDWVKPQS SCCRVHSSSG
QFCNASVADP GCIRCRPLTP EGKQRPQGGD FMRFLPMFLS DNPNPKCGKG GHAAYGSAVN
ILGNDTGVGA TYFMTYHTVL QTSADFIDAM RKARLIAGNI TQTMSQGGSN YRVFPYSVFY
VFYEQYLTII EDTVFNLCVS LGAIFLVTVV LLGCELWSAV IMCVTIAMIL VNMFGVMWLW
GISLNAVSLV NLVMSCGISV EFCSHITRAF TVSPKGSRVA RAEEALSHMG SSVFSGITLT
KFGGIVVLAF AKSQIFQIFY FRMYLAMVLL GAAHGLVFLP VLLSYIELTP RHTWSGPSSP
PAPTVGADLP WSQCPDSELA ELGDLQ
//
