ID S7NA88_MYOBR Unreviewed; 300 AA.
AC S7NA88;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE SubName: Full=SH2B adapter protein 3 {ECO:0000313|EMBL:EPQ13956.1};
GN ORFNames=D623_10011521 {ECO:0000313|EMBL:EPQ13956.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13956.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; KE163810; EPQ13956.1; -; Genomic_DNA.
DR AlphaFoldDB; S7NA88; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10412; SH2_SH2B3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035059; SH2B3_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF1; SH2B ADAPTER PROTEIN 3; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 1..40
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 97..195
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 42..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 33179 MW; 29BA1395D884201C CRC64;
MPDNLYTFVL KVKDRTDIIF EVGDEQQLNS WMAELRKCTG QGLESTDPEL HVPSAPEPGT
ASSPRGSTDS LNQGASPGGL LDPACQKTDH FLSCYPWFHG PISRVKAAQL VQLQGPDAHG
VFLVRQSETR RGEYVLTFNF QGIAKHLRLS LTERGQCRVQ HLHFPSVMDM LHHFQRSPIP
LECGSACDVR LSSYVVVVSQ PPGSSNTVLF PFSLSRWDSE LGLPHLSSSG CPRGLGPEGL
PGRSSPQEQI FHLVPSPEEL ANSLRHLESE PANRARDSDY EMDSSSRSHL RAIDNQYTPL
//
