ID S7NEL8_MYOBR Unreviewed; 1180 AA.
AC S7NEL8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Protocadherin-18 {ECO:0000313|EMBL:EPQ14875.1};
GN ORFNames=D623_10033269 {ECO:0000313|EMBL:EPQ14875.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ14875.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164069; EPQ14875.1; -; Genomic_DNA.
DR AlphaFoldDB; S7NEL8; -.
DR eggNOG; KOG3594; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF9; PROTOCADHERIN-18; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1180
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004543316"
FT TRANSMEM 694..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..350
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 365..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..572
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..688
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 764..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 130651 MW; A55283B01AB023DF CRC64;
MNAKMHSRLV FALLVVSFNP DVWGKNLKYR IYEEQRVGSV IARLSEDVAD VLAKLPYPYV
RFRAMQRGNS PLLVVNEDTG EISIGAKIDR EQLCQKNLNC SIEFDVITLP TEHLQLFHIE
VEVLDINDNA PQFSRPLIPI EISESAAVGT RIPLDSAFDP DVGENSLHTY SLSANEFFSI
EVRTRTDGAK YAELIVVREL DRELKSSYEL QLTASDMGVP QRSGSSILKI SISDSNDNSP
VFEQQSYIIQ LLENSPVGTL LLDLNATDPD EGANGKIVYS FSSHVSPKII ETFKIDSERG
HLTLFKQVDY EITKSYEIDV QAQDLGPNSI PAHCKIVIKV VDVNDNKPEI NINLMSPGKE
EISYIFEGDP VDSFVALVRV QDKDSGLNGE VVCKLHGHGH FKLQQSYENN YLILTNATLD
REKRSEYSLT VIAEDKGTPS LSTVKHFTVQ ISDINDNPPH FQRSRYELAI SENNSPGAFI
TTVTATDPDL GENGQVTYTI LESFILGSSI TTYVTIDPSN GGIYALRNFD HEEVSQITFV
VEARDGGSPK QLVSNTTVVL TIIDENDNVP VVIGPTLRNN TAEISIPKGA ESGFHVTRIR
AIDRDSGVNA ELSCSIVAGN EENIFVIDPR SCDIHTNVSM ESVPSTEWEL SVIIQDKGNP
QLHTKVLLKC MIFKYAESVT STAKTPASQE SLDVSMIIII SLGAICAVLL VIMVLFATRC
NREKKDTRSY NCRVAESTYQ HHPKRPSRQI HKGDITLVPT INGTLPIRSH HRSSPSSSPT
LERGQMGSRQ SHNSHQSLNS LVTISSNHVP ENFSLELTHA TPAVEQVSQL LSMLHQGQYQ
PRPSFRGNKY SRSYRYALQD MDKFSLKDSG RGDSEAGDSD YDLGRDSPID RLLGEGFSDL
FLTDGRIPAG EIAPPGKALK EGQRDQPLTP LANKSYSLDM ILSHSKCTHE SPLFPLRAAM
RLCTEECRVL GHSDQCWMPP LPSPSSDYRS NMFIPGEEFP AQPQQQHPHQ GLEDDTQPAD
SGEKKKSFST FGKDSPKEED PGDKGTSSLL SEMSSVFQRL LPPSLDTYSE ASEVDRSNSL
ERRKGPLPAK TGGYPQGVAA WAASTHFQNP TTNSGPPLGT HSSVQPSAKW LPAMEEIPEN
YEEDDFDNVL NHLNDGKHEL MDASELVAEI NKLLQDVRQS
//
