ID S7NFY8_MYOBR Unreviewed; 619 AA.
AC S7NFY8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sorting nexin-7 {ECO:0000313|EMBL:EPQ15350.1};
GN ORFNames=D623_10018734 {ECO:0000313|EMBL:EPQ15350.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15350.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KE164129; EPQ15350.1; -; Genomic_DNA.
DR AlphaFoldDB; S7NFY8; -.
DR eggNOG; KOG2273; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03384; PAP2_wunen; 1.
DR CDD; cd07284; PX_SNX7; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042130; PX_SNX7.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR PANTHER; PTHR45949:SF3; SORTING NEXIN-7; 1.
DR Pfam; PF01569; PAP2; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00014; acidPPc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 401..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..142
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 619 AA; 69989 MW; FCBCE01AACBC0ECA CRC64;
MPTSPLSMIN QVKFEDEPDL KDLFITVDDP ESHVTTIETF ITYRVATQTS RGEFDSSEFE
VRRRYQDFLW LKGKLEEAHP TLIIPPLPEK FVVKGMVERF NDDFIETRRR ALNKFLNRIA
DHPTLTFSED FKVFLTAQAG ELSSHKKQGP GLLSKMGQTV RAVALSLRGV RSRPEEFTEM
SDFIETFSQK INLIDKISQR IYKEEREYFD EMKEYGPIHA LWSESEEDLA DTLGSMASCL
DRCCQATERR LCGLSEALLP VVHEYVLYSE MLMGVMRRRD HIQAELESKA EALTYKKVDT
DLLTEEIGKL EDKVECANTA LRADWERWKQ NMRNDIKSAF ADTAERNIHY YEQLPILASS
VVSLYFLELT DVFKPVHSGF SCYDRSLSMP YIEPTQEAIP LLMLLSLAFA GPAITIMVGE
GILYCCLSKR RNGVGLEPNI NAGGCNFNSF LRRAVRFVGV HVFGLCSTAL ITDIIQLSTG
YQAPYFLTVC KPNYTSLNVS CKENSYIVED ICSGSDLTVI NSGRKSFPSQ HATLAAFAAV
YVSMYFNSTL TDSSKLLKPL LVFTFIICGI ICGLTRITQY KNHPVDVYCG FLIGGGIALY
LVNGCYHYGT SHGLTWNPA
//
