ID S7NG27_MYOBR Unreviewed; 2709 AA.
AC S7NG27;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Interphotoreceptor matrix proteoglycan 2 {ECO:0000313|EMBL:EPQ16404.1};
GN ORFNames=D623_10018057 {ECO:0000313|EMBL:EPQ16404.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16404.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix {ECO:0000256|ARBA:ARBA00004593}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KE164256; EPQ16404.1; -; Genomic_DNA.
DR eggNOG; ENOG502QT6W; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039861; IMPG.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR049109; TARSH/FNDC1_C.
DR PANTHER; PTHR12199; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN; 1.
DR PANTHER; PTHR12199:SF4; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF01390; SEA; 2.
DR Pfam; PF21731; TARSH_C; 1.
DR SMART; SM00200; SEA; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50024; SEA; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:EPQ16404.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..2709
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004543331"
FT TRANSMEM 1110..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1194..1222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..354
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 907..1020
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1020..1061
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1315..1413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2474..2567
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 44..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..2477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2547..2578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1823..1843
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1966..1981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2207..2253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2357
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2364..2389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2390..2405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2426..2440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2556..2570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1029..1046
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2709 AA; 300486 MW; 325A366CF3BD5734 CRC64;
MIMFPHSGKI SLGILIFVLI EENLSSLTAQ SYLSLEETQE PTSAISLLPP DSESADSSLS
SGNKRPRDHR EAERHWLLRR RRSTLFPNGV KICPDESVTE AVANHVKYFQ VRVCQEAVWE
AFRTFWDRLP GSEEYRYWMN LCEDEITTIF EMGTNFSQSV EHRSLIMKKL AYTKETVSRP
ELSSLVPVGD TSTLEGAALR VPYPGVTSSA GTLESSLGRP EESINNEIET VIEESTKPAA
EQIAEFSIHL LGEQYREELR DPSSFHHQSL VEEFIAEIEN AFTGLPGYKD IRVLDFRSPE
ENGSGTDVHY AVTFNGEAIS NTTWDLISLH SNKVENHGLV ELDDKPTAVY TISNFRDYIA
ETLHHNFLLG NSSLNPDPGS LQLINVRGVF LPPTEDPVWN PQSASLPATP PSVLDNTLQA
AWPSADDSTT SSISLLDFSS GSPSATGREL WLARPLGDLV STPKLDFPSK VGLHSSPEVL
EVSSLTLHSV TPAVLLTGLP VASEERTSGS YLLEEGLTKV EGSEDSFSGD PLPSTHPLTH
PVPEETIPSK EDSVVSLTSS QFLVSSVTLD PLAQEVSTPS GLDPSASKVK DQLEVSTLMP
DTSMEKEFTF ESGLDSGSGE KVSGITWPWS DTSLEKSIEP LTKSWLEDED SLLPIESVDE
KLVVGDKIVS TDRSIEHSKY GHFDRSTHFS EEEPLEGPTV PFSAETTTQS APLILSEVPD
IDYYSVTHAP PLLTSTAISD STDKPDQVEP FLKEDMEQTT EPSNRKQFDS KISTLKPDMQ
SLWTILPESD VVWEKTSSLG KLSGDTLASA PESIDKLWLK ASMTQSTELP PTTSPTLLED
EVIMGVQDIS LELDRIGTDY YQPELIPEEN GRVGSYVEIS TNVHSTEMAI VAHPTKRGDS
NHTQTTGALL VFFSLRVTNM MFSEDLFNKN SLEYKALEQR FLELLVPYLQ SNLTGFQNLE
ILNFRNGSIV VNSRMKFSKS VPPNVNNAVY MILEDFCTTA YQTMNLAIDK YSLDVESGDE
ANPCKFQACN EFSECLVNPW SGEAECRCYP GYLSVEELPC QSLCDLQPDF CFNDGKCDIM
PGHGAICRCR VGENWWYRGE HCEEFVSEPL VIGITIAAVV GLLLVSSAVV IFLIKTLQAQ
NAQRERERPF RFNKYLQVIC FGPDCVFFFF FFFFFFFFFF FFFFFFFFFF FFFFFFFFFF
FFFFFFFFFF FFFFFFFFFF FFTTLRKRPS LKVHINTTSD SIFLKFLRPN PNVKLEGFLL
GYGSNLSPNQ YFPLPAEGKY TEAVVDAEPK YLIVVRPAPP PSQKKSCSGK TRSRKPLQLV
VGTLTPSSVF LSWGFLINPH HDWTLPSHCP NDRFYTIRYR EKDKEKKWIF QLCPATETIV
ENLKPNTVYE FGVKDNVEGG IWSKIFNHKT IIGSINKVNG KIQSTYDQAN TVPAYVPRKL
IPITIIKQVI QNVTHRASTK SPDRTPIGGT ILVHLVIPGL NETTVKLPTS IMFEISEAIK
TQLAKNETLA LPAESKTPKV EKIPAQPITV TPDSVPGTTK STVSSALDIS ETTLASSEKP
WIAPITKTSE DSKVLPPQTA AYDVFSSPTT SDEPEISEPH TATTDPFLDS VPPKTSRTLE
QPRATLAPLQ TTPKRRLRPK PPRTKPERTK SPGTTTSKLS VSPEPTWTTL GNDMSLVAPS
KTQFISLKPK IPLSPEVTHV KPAPEPLTPT PSQSTIALEP GTLETKPSTT TLAPPKTKRP
GRRPRPKTTR SPDVPKSKPA LQPATVQPEL WVPTVDSKPP KQLLPKPQTT AKPDMPSTKS
GFEPVTLEAG APSITIAPKT SKRPRTRPPR PKPSKRPKPS KPPKHPKHET TPSPEAPATA
LAPTTTKRPR RPRPKPKKTT PHPEVPQIPL VPATIFEPVI PRTEAPGTTL VPATIFEPVV
PRTEAPGTTL APKVPEQTHH PRPKPKTTPS PAAPQTELVP ITDLGPVTFT TETSGTTLAT
KASKRPHRPH LRPKTTLSPQ VPQTKPVSKP SQRKGRPCPR PKTTPGPETP ESKPAPKPSK
RTRRPRPKPK TTPTTEAPQT KLVPITDLEP GTPRTEAPEI VASAETDYVD PTSKAPLRPE
EPKTEGVVES ITNVSEPPET ALAPKQTART PPKAKTSPRP RVPQTQPAPK VFQRVTSKPK
MSPRPEASYT PPGDVLRPQK PDHEVSQREP VLQPVTFRID PPETTIAPLE TRSSPFIPMI
SPSSSQEDLQ TALAETDQST QELFTTKIPR TTELAKTTRA PHRLYTTPGR PKIPEKPPLR
PVLNKTTTRP TRPKPNGMPK GTEMGTGVKQ PPKPSGAGRN ASMDSTHFTK KPAIIPGTRR
PPLPPRPTPP RRKPLPPNNV TGKPGSAGII SSGLGTSPPL RATLRPTGPT SERTERDKKE
PTAPASGEDL GDITDFSSSP TRETDPLGKP RFKGPHVRYI QKPDNRPCSI TDSIKRFPKE
EPPEGNATSP PQNPPSNLTV VTVEGCPSFV ILDWEKPPND TVTEYEVISR ENGSFSGKNK
SIQITNQTFS TVENLKPNTS YEFQVKPKNP LGEGPPSTTV AFSTESADPR VSEPVSGGRD
AIWTERPFDS DSYSECKGKQ YVKRTWYKKF VGVQLCNSLR YKIYLSDSLT GKFYNIGDQR
GHGEDHCQFV DSFLDGRTGQ QLTSEQLPTK EGFFRAVRQE PVQFGEIGGH TQINYVQWYE
CGTTIPGKW
//
