ID S7NG44_MYOBR Unreviewed; 2491 AA.
AC S7NG44;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase 24 {ECO:0000313|EMBL:EPQ15425.1};
GN ORFNames=D623_10020495 {ECO:0000313|EMBL:EPQ15425.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15425.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164147; EPQ15425.1; -; Genomic_DNA.
DR MEROPS; C19.047; -.
DR eggNOG; KOG1866; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR CDD; cd17065; Ubl_UBP24; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR047061; UBP24_Ubl.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF729; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 24; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EPQ15425.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 1558..1911
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 902..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1790..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1932..1959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2446..2491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2446..2471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2491 AA; 281210 MW; 5B940C0B4ACC4A9A CRC64;
MTATGAPAHL LHHPATADNA SMFRMRLLVV SAHSLSESDE NCKRFMDRCM PEAFKKLLTS
SAVHKWGTEI HEGIYNMLML LIELVAERIK QDPIPIGLLG VLTMAFNPDN EYHFKNRMKV
SQRNWAEVFG EGNMFAISPV STFQKEPHGW VVDLVNKFGE LGGFAAIQAK LRSEDIELGA
VSALVQPLGV CAEYLNSSVV QPMLDPVILT TIQDVRSVEE KDLKDKRLVS IPELLSAIKL
LCMRFQPDLV TVVDDLRLDI LLRMLKSPHF SAKMNSLKEV TKLIEDSTLS KSVKNAIDTD
RLLDWLVENS VLSIALEGNI DQAQYCDRIK GIIELLGSKL SLDELTKIWK IQSGQSSTVI
ENIHTIIAAA AVKFNSDQLN HLFVLIQKSW EIESDRVRQK LLSLIGRIGR EARFETTSGK
VLDVLWELAH LPTLPSSLIQ QALDEHLTIL SDAYAVKEAI KRSYIIKCIE DIKRPGEWSG
LEKKKDGFKS SQLNNPQFVW VVPALRQLHE ITRSFIKQTY QKQDKSIIQD LKKNFEIVKL
VTGSLIACHR LAAAMAGPGG LTGSTLVDGR YTYREYLEAH LKFLAFFLQE ATLYLGWNRA
KEIWECLVTG QDVCELDREM CFEWFTKGQH DLESDVQQQL FKEKILKLES YEITMNGFNL
FKTFFENVNL CDHRLKRQGA QLYVEKLELI GMDFIWKIAM ESPDEEIANE AIQLIINYSY
INLNPRLKKD SVSLHKKFIA DCYTRLEAAS SALGGPTLTH AVTRATKMLT ATAMPTVATS
VQSPYRSTKL VIIERLLLLA ERYVITIEDF YSVLRTILPH GASFHGHLLT LNVTYESTKD
TFTVEAHSNE TIGSVRWKIA KQLCCPVDNI QIFTNDSLLT VNKDQKLLHQ LGFSDEQMLT
VKTSGSGTPS GSSADSSTSS SSSSSGVFSS SYAMEQEKSL PGVVMALVCN VFDMLYQLAN
LEEPRITLRV RKLLLLIPTD PAIQEALDQL DSLGRKKTLL SETSSQSSKS PSLSSKQQHQ
PSASSILESL FRSFAPGMST FRVLYNLEVL SSKLMPTADD DMARNCAKSF CENFLKAGGL
SLVVNVMQRD SIPSEVDYET RQGVYSICLQ LARFLLVGQT MPTLLDEDIA KDGIEALSSR
PFRNVSRQTS RQMSLCGTPE KSSYRQLSVS DRSSIRVEEI IPAARVAIQT MEVNDFTSTV
ACFMRLSWAA AAGRLDLVGS SQPIKESNSL FPAGIRNRLS SSGSNCSSGS EGEPVALHAG
ICVRQQSVST KDSLIAGEAL SLLVTCLQLR SQQLASFYNL PCVADFIIDI LLGSPSAEIR
RVACDQLYTL SQTDTSTHPD VQKPNQFLLG VILTAQLPLW SPTSIMRGVN QRLLSQCMEY
FDLRCQLLDD LTTSEMEQLR ISPATMLEDE ITWLDNFEPN RTAECETSEA DNILLAGHLR
LIKTLLSLCG AEKEMLGSSL IKPLLDDFLF RASRIILNSH SPAGSAAISQ QDFHPKCSTV
NSRLAAYEVL VMLADSSPSN LQIITKELLS MHHQPDPALT KEFDYLPPVD SRSSAGFVGL
RNGGATCYMN AVFQQLYMQP GLPEALLSVD DDTDNPDDSV FYQVQSLFGH LMESKLQYYV
PENFWKIFKM WNKELYVREQ QDAYEFFTSL IDQMDEYLKK MGRDQIFKNT FQGIYSDQKI
CKDCPHRYER EEAFMALNLG VTSCQSLEIS LDQFVRGEVL EGSNAYYCEK CKEKRITVKR
TCIKSLPSVL VIHLMRFGFD WESGRSIKYD EQIKFPWMLN MEPYTVSGMA RQDSSSEVGE
NGRSMDQGGG GSPRKKVALT ENYELVGVIV HSGQAHAGHY YSFIKDRRGC GKGKWYKFND
TVIEEFDLND ETLEYECFGG EYRPKVYDQT NPYTDVRRRY WNAYMLFYQR VSDQNSPVLP
KKSRVSVVRQ EAEDLSLSAP SSPEISPQSS PRPHRPNNDR LSILTKLVKK GEKKGLFVEK
MPVRIYQMVR DENLKFMKNR DVYSSDYFSF VLSLASLNAT KLKHPYYPCM AKVSLQLAIQ
FLFQTYLRTK KKLRVDTEEW IATIEALLSK SFDACQWLVE YFIGSEGREL IKIFLLECNV
REVRVAVATI LEKTLDSALF YQDKLKSLHQ LLEVLLALLD KDVPENCKNC AQYFFLFNTF
VQKQGIRAGD LLLRHSALRH MISFLLGASR QNNQIRRWSS AQAREFGNLH NTVALLVLYS
DVSSQRNVAP GVFKQRPPIS IAPSSPLLPL HEEVEALLFL SEGKPYLLEV MFALRELTGS
LLALMEMVVY CCFCNEHFSF TMLHFIKNQL ETAPPHELKN TFQLLHEILV IEDPIQVERV
KFVFETENGL LGKALMHHSN HVDSSRCYQC VKFLVTLAQK CPAAKEYFKE NSHHWSWAVQ
WLQKKMSEHY WTPQSNVSNE TSTGKTFQRT ISAQDTLAYA TALLNEKEQS GSSNGSESSP
ANENGDRHLQ QGSESPMMIG ELRSDLDDVD P
//
