ID   S7NGS5_MYOBR            Unreviewed;       810 AA.
AC   S7NGS5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Cas scaffolding protein family member 4 {ECO:0000313|EMBL:EPQ16704.1};
GN   ORFNames=D623_10013763 {ECO:0000313|EMBL:EPQ16704.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16704.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|ARBA:ARBA00004246}.
CC   -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR   EMBL; KE164286; EPQ16704.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7NGS5; -.
DR   eggNOG; ENOG502QUJM; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd12000; SH3_CASS4; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR   Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR021901; CAS_C.
DR   InterPro; IPR037362; CAS_fam.
DR   InterPro; IPR035744; CASS4_SH3.
DR   InterPro; IPR014928; Serine_rich_dom.
DR   InterPro; IPR038319; Serine_rich_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR   PANTHER; PTHR10654:SF19; CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4; 1.
DR   Pfam; PF12026; CAS_C; 1.
DR   Pfam; PF08824; Serine_rich; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          18..80
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          184..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   810 AA;  88791 MW;  B8A13E303744384E CRC64;
     MGLPVQFRRK MTKNQTKNDA LLARALYNND PDCSDELAFC KGDILTILEQ HVPESKGWWR
     CLLHGRQGLA PANRLQILSG APADSPCPPF LRPLEEALAS SKEAYQVPTL LSPPPPGPVY
     EPMKSWVTGP PPHTVQVYEL PDPPASARIV CEKMPSFSKQ AIVPIPRPAQ ASLLTLYDVP
     AQSRGPSALK EPGKQQLYDI PASPRKAERG PPAGQPSRQS APVTATVALG RACYKTLPNP
     QKSEWIYDTP VSPAKADVRN VCVTGFVEES GSHALPRSMS SFHSPPNSRA RSLAPHLRGN
     VPVQNPSLPE VPACPRPAPG DACPSDRGVS YKIPLSFLIP RVEQQNTKPN IYDIPIPVPS
     APRAGKEPGD ADRASGETSD PHCACLSRQA TWPAPEPDRL SVNSSDSRAS ITSSCSSMST
     DSSCSSSSEE SAKELSLDLA LAKGTATALQ QKVASSVAGL MLFVSRNWRL RDSLEANIDA
     IRRAADLIEE SLREFLDFAR GVCGATGNLP SSSLQARIRD QLQTISNSYH ILLETKESLE
     GCHWSLDVLV TDKAQSSLDD LERFVMVARM VPEDIKRFTS IVIANGRLLF KQNGEKEETP
     PWAPKTEFKL AKGIQLPRRE TESYQRSAPR PQQRESGPCP ELLGKSWASV YEKKLPNLEE
     KVKPILEQRL DENKDLETQD LSSPVQQDPG KKAHLSEHCR LYFGALFKAM GVLHSSLRHS
     QPPEILVAQS KLVITIGQKL VDTLCRETQD RDARNEILRG SSHLCSLLKD LALATKRAVL
     QRPSPAALAH LRAEADKLEQ HARQFRGSLD
//