ID S7NID5_MYOBR Unreviewed; 802 AA.
AC S7NID5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 {ECO:0000313|EMBL:EPQ16325.1};
GN ORFNames=D623_10012653 {ECO:0000313|EMBL:EPQ16325.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16325.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR EMBL; KE164246; EPQ16325.1; -; Genomic_DNA.
DR RefSeq; XP_005880149.1; XM_005880087.2.
DR AlphaFoldDB; S7NID5; -.
DR GeneID; 102252647; -.
DR CTD; 116988; -.
DR eggNOG; KOG0705; Eukaryota.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08855; ArfGap_AGAP3; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF2; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 311..532
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 553..673
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 712..744
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 371..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 87148 MW; 7A5AA145CC2C2DC0 CRC64;
MEDLALQNQI REHVISIEDS FVNSQEWTLS RSVPELKVGI VGNLSSGKSA LVHRYLTGTY
VQEESPEGGR FKKEIVVDGQ SYLLLIRDEG GPPELQFAAW VDAVVFVFSL EDEISFQTVY
NYFLRLCSFR NASEVPMVLV GTQDAISAAN PRVIDDSRAR KLSTDLKRCT YYETCATYGL
NVERVFQDVA QKVVALRKKQ QLAIGPCKSL PNSPSHSAVS AASIPSVHIN QATNGGSSAF
SDYSSSVPST PSISQRELRI ETIAASSTPT PIRKQSKRRS NIFTSRKGAD LDREKKAAEC
KVDSIGSGRA IPIKQGILLK RSGKSLNKEW KKKYVTLCDN GLLTYHPSLH DYMQNVHGKE
IDLLRTTVKV PGKRLPRATP ATAPGTSPRA NGLALDRSNT QLGGGTGAPH SASSPAWAGL
RPEGLHQRSC SVSSADQWSE AAALPPASGP AEVLGSSPKL EPPPSPHSNR KKHRRKKSTG
TPRPDGPSSA AEDVEESFEF VVVSLTGQTW HFEASTAEER ELWVQSVQAQ ILASLQGCRS
AKDKTRLGNQ NTALAVQAVR TVRGNSFCID CDAPNPDWAS LNLGALMCIE CSGTHRHLGA
HLSRVRSLDL DDWPPELLAV MTAMGNALAN SVWEGALDGY AKPGPDACRE EKERWIRAKY
EQKLFLAPLP SSDVPLGQQL LRAVVEDDLR LLVMLLAHGS KEEVNETYGD GDGRTALHLS
SAMANVVFTQ LLIWYGVDVR SRDARGLTPL AYARRAGSQE CADILIQHGC PGEGCGLTPT
PNREPANGTN TSAELHRSPS LL
//
