ID S7NT47_MYOBR Unreviewed; 3088 AA.
AC S7NT47;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Dynein heavy chain 10, axonemal {ECO:0000313|EMBL:EPQ20301.1};
GN ORFNames=D623_10013056 {ECO:0000313|EMBL:EPQ20301.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20301.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KE164810; EPQ20301.1; -; Genomic_DNA.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 374..510
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 688..831
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1046..1197
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1662..1728
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1876..1938
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3088 AA; 352456 MW; AD059B985BE1A846 CRC64;
MNTWQEVVEG KLPVTTGLPR DWFLGCVEPG RRQVPDLCPL DLVQIMGETL KDPVIKRCCE
APNRLSDLQH ISEGLEKCQK SLNDYLDSKR NAFPRFFFIS DDELLSILGS SDPLCVQEHM
IKAALRLQSS APVSRGVSVV LQMYDNIAAL RFQDGDSGEK LVSAMISAEG EVMEFRKTVR
AEGRVEDWMT AVLNEMRRTN RLITKEAIFR YCEDRSRVDW MLLYQGMVVL AACQVWWTWE
VEDVFHQVQA GEKHAMKSFG RKMHRQIDEL VTRITLQLGK NDRKKYNTEL IIDVHARDIV
DSFIRGSILD AQEFEWESQL RFYWDREPDE LNIRQCTGTF GYGYEYMGLN GRLVITPLTD
RIYLTLTQAL SMYLGGAPAG PAGTGKTETT KDLAKALGLL CVVTNCGEGM DYKAVGKIFS
GLAQCGAWGC FDEFNRIDAS VLSVISSQIQ TIRNALMHQL TTFQFEGQEI SLDSRMGIFI
TMNPGYAGRT ELPESVKALF RPVVVIVPDL QQICEIMLFS EGFLWAKTLA KKMTVLYKLA
REQLSKQHHY DFGLRALKSV LVMAGELKRG SSELKELYAR FAVRDATHVL CEGSWTRALG
NTRDVCVPPT QDVVLMRALR DMNLPKFVFE DVPLFLGLIS DLFPGLDCPR VRYPSFNDAV
EQVFEENGFV VLPVQVDKVI QVYETMLTRH TTMVVGPTGG GKSVVINTLC QAQTKLGLTT
KLYILNPKAV SVIELYGILD PSTRDWTDGV LSNIFREINK PTDKKERKYI LFDGDVDALW
VENMNSVMDD NKLLTLANGE RIRLQAHCAL LFEASGREIT WTEVLLFVKV GDLQYASPAT
VSRCGMVYVD PKNLKYQPYW KKWLQQIQNK VEQVQLQNLF EKYVPYLIDV IVEGIVDGRQ
GEKLKMIVPQ TNLNMVTQLT KVLDAFLEGE IEDPDLLECF FLEALYCSLG ACLLDFGRNR
FDECIKRLAS LPSAELDGVW AQPGELPAQL PTLYDFHFDP AQKRWIPWSK LVPEYVHSRE
RRFIEILVHT VDTTRTAWML ERMVKIKHPV LLVGESGTSK TATTQNFLKN LSEETNIVLM
VNFSSRTTSL DIQRNLEANV EKRTKDTYGP PMGKRLLVFM DDMNMPKVDE YGTQQPIALL
KLLLEKGFLY DRGKELNCKS IRDLGFIAAM GKAGGGRNEV DPRFLSLFSV FNVPFPSEMS
LHLIYFSILR GHTSVFHESI IAVSDRLTRC TLQLYTDIVQ ELPPTPSKFH YIFNLRDLSR
VFHGLVLTNP ERFQTVAQMV RVWRNECLRV FHDRLINEDD KALVQEYISD LVTEHFKDDV
EVVMRDPILF GDFRMALHEE EERIYEDIQD YEAAKALFQE ILEEYNESNT RMDLVLFDDA
LEHLTRVHRI IRLDRGHALL VGVGGSGKQS LAKLAAFTAG YEVFEILLSR GYSESNFRED
LKNLYLRLGI ENKTTIFLFT DAHVVEEGFL ELINNMLTSG PEGLPAPGNP PVLVPGMVPA
LFAEDEKETI LGQIDQEALK QGVSPAKESV WQYFVNKSAN NLHIVLGMSP VGDALRTWCR
NFPGLVNNTG IDWFMPWPPQ ALHAVAKSFL GPNTMIPEEH IEDLVEHVVL VHGSVGEFSK
QFLQKLRRSN YVTPKNYLDF INTYSKLLDE KTQNNIAQCK RLEGGLDKLK EASIQLDELN
RKLAEQKIVL AEKSTACETL LDEIVTNTAT AEEKKKLAEE KAIDIEEQNK IIAVEKAEAE
TALAEVMPIL EAAKLELQKL DKSDVTEIRS FAKPPKQVQT VCECILIMKG YKELNWKTAK
GMMSDPNFLR SLMEIDFDSI TQGQVKNIRS LLKTLNTTIE EMEAVSKAGL GMLKFVEAVM
SYCDVFKEIK PKREKVARLE RNYFLTKREL EKIQNELAAL QRELEALGAK YEAAILEKQK
LQEEAEIMER RLIAADKLIS GLGSENVRWL RDLDELMHRR VRLLGDCLLC AAFLSYEGAF
TWEFRNEMVN QVWQQDITER EIPLSVPFRL ESLLTDEVEI SRWGSQGLPP DELSIQNGIL
TTRASRFPLC IDPQQQALNW IKRKEEKNNL RVASFNDPDF LKLLEMSIKY GTPFLFHDVD
EYIDPVIDNV LEKNIKFSQG RQFIILGDKE VDYDSNFRLY LTTKLANPRY TPSVFGKAMV
INYTVTLKGL EDQLLSVLVA FERHELEEQR EHLIQETSEN KNLLKDLEDS LLRELATSTG
NMLDNVELVQ TLEETKSKAT EVSEKLKLAE KTALDIDRLR DGYRPAARRG AILFFVLSEM
ALVTTMYQYS LSAFLDVFGL SLKKSLPDSI LMKRLRNIMD TLTFNIYNYG CTGLFERHKL
LFSFNMTIKI EQAEGRVPQE ELEFFLKGNI SLEKSKRKKP CAWLSDQGWE DIMLLSELFS
EDFGSLPDDV EKHPAVWQEW YDLDALEQSP FPLGYDSSIT PFQKLLILRC FRVDRVYRAV
TDYVTVTMGE KYVQPPMISF EAIFEQSTPN SPIVFILSPG SDPASDLMKL AEQTGFGGNR
LKFLAMGQGQ EKVALQLLET AVARGQWLML QNCHLLVKWL KDLEKSLERI TKPHPDFRLW
LTTDPTQGFP IGILQKSLKV VTEPPNGLKL NMRATYFKIS NEMLERCPHP AFKPLVYVLA
FFHAVVQERR KFGKIGWNVS YDFNESDFQV CMEILNTYLT KAFQQRDTRI PWGSLKYLIG
EVMYGGRAID SFDRRILTIY MDEYLGDFIF DTFQPFHFFH NKEVDYKIPA GAGDPKERFV
EAIEALPLAN TPEVFGLHPN AEIGYYTQAA RDLWSHLLEL QPQTGESSSG ISREDYIGNV
AKDIENKMPK VFDLDLVRRH LGASITPTSV VLLQELERFN KLLVRMSRSL AGLQRALAGE
VGMSSELDDV ARSLFIGNIP HIWRKLAPDT LKSLGNWMLY FLRRFSQYTS WVVESEPNVM
WLSGLHVPES YLTALVQATC RRNGWPLDRS TLFTQVTKFQ DADEVTERAG QGCFVSGLYL
EGADWDLERG CLVKSKPKVL VVDLPILKII PIEAHRLKLQ NTFRTPVYTT STRRNAMGVG
LVFEADLFTT RHISHWVLQG VCLTLNSD
//
