ID S7P621_MYOBR Unreviewed; 523 AA.
AC S7P621;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=WSC domain-containing protein 1 {ECO:0000313|EMBL:EPQ03147.1};
DE Flags: Fragment;
GN ORFNames=D623_10008587 {ECO:0000313|EMBL:EPQ03147.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03147.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR EMBL; KE161326; EPQ03147.1; -; Genomic_DNA.
DR AlphaFoldDB; S7P621; -.
DR eggNOG; KOG4157; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 23..115
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 126..221
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPQ03147.1"
SQ SEQUENCE 523 AA; 59960 MW; 3FCDAACB3E65DE1A CRC64;
FMADPQELPA LGPVAPRPAA SSRGTYVGCF RDDGQERTLK GTVFFDLRKM TVSHCQDACA
ERSYVYAGLE AGTECYCGNR LPVLSVGPEE CKHECKGEKG SACGGVGRLS VYRVEELQPS
SRKRRSVTYR GCFRLPENIT HAFPDSLIQA NVTVETCSGF CSKKEFPLAI LRGWECYCAY
PTSQFNLRDA VDSSLCGQES EAQKLAEYCE VYQTPVQDTR CTDRRFLPTK SKVFVALSSF
PGAGNTWARH LIEHATGFYT GSYYFDGTLY NKGFKGEKDH WRSRRTICVK THESGRREIE
MFDSAILLIR NPYRSLVAEF NRKCAGHLGY AADRNWKSKG FKGEKDHWRS RRTICVKTHE
SGRREIEMFD SAILLIRNPY RSLVAEFNRK CAGHLGYAAD RNWKSKEWPD FVNSYASWWS
SHVLDWLKYG KRLLVVHYEE LRRSLVPTLR EMVAFLNVSV SEERLLCVEN NKEGSFRRHG
RRPHDPEPFT PEMKDLINGY IRTVDKALRD HNWAGLPREY VPR
//
