ID S7PFY3_MYOBR Unreviewed; 1356 AA.
AC S7PFY3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=D623_10033478 {ECO:0000313|EMBL:EPQ06867.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06867.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KE162063; EPQ06867.1; -; Genomic_DNA.
DR RefSeq; XP_005864868.1; XM_005864806.2.
DR GeneID; 102245110; -.
DR KEGG; myb:102245110; -.
DR CTD; 2956; -.
DR eggNOG; KOG0217; Eukaryota.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd05837; PWWP_MSH6; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00855; PWWP; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 88..150
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1356 AA; 152127 MW; 4B972E1DF0777DAD CRC64;
MSRQSTLYSF FPKSPAGLSN ASKAPVKASG EGGAVAAAGA SPSPSEEVAR SEVGPGRSAS
PSEARNLNGG LRRSTAPADS SSSCDFSPGD LVWAKMEGYP WWPCLVYNHP FDGTFIREKG
KSARVHVQFF DDSPTRGWVS RRLLKPYTGS KSKEAQKGGH FYSAKPEILR AMQRADEALT
KDKIKRLELA VCDEPSEPEE EEMEVGATYT SDKNEEDNEI ESEEEVRPKV QGSRRSSRQI
KKRRVISDSE SDNGGSDVEF KPDAKEEGSS DEISSGVGDS DSEGLHSFVK VAPKRKRMVT
GNGSLKRKSS RKEMPPISKR ATGISSETRS TLCAFSAAQN SESLAHNSGR CDDNSRPAVW
YHETLEWLKE EKRRDVHRRR PDHPDFDAST LYVPEDFLNS CTPGMKKWWQ IKSQNFDLVI
FYKVGKFYEL YHMDALIGVS ELGLVFMKGN WAHSGFPEIA FGRYSDSLVQ KGYKVARVEQ
TETPEMMEAR CRKMAHISKH DRVVRREICR IITKGTQTYS VLEGDPSENY SKYLLSLKEK
EEDTSGHTRV YGVCFVDASL GKFFIGQFSD DRHCSRFRTL VAHYPPVQVL FERGNLSTET
KMILKGSLSS SLQEGLIPGS QFWDAAKTLR TLLEEGYFKE KLNEDSGVVL PHVLKGMTSE
SDSIGLTPGE KSELALSALG GCVFYLKKCL IDQELLSMAN FEEYIPLDSD MVSVIRPGAI
FSKVNQRMVL DSVTLNNLEI FLNGTNGSTE GTLLEKIDTC HTPFGKRLLK QWLCAPLCNP
FAINDRLDAI EDLMFVPDKI TEVVDLLKKL PDLERLLSKI HNVGSPLKSQ NHPDSRAIMY
EETTYSKKKI IDFLSALEGF KVICKIIGIM EEVIDDFKSK ILKQVITLQT KNPEGHFPDL
TVELNRWDTA FDHEKARKTG VITPKVGFDS DYDQALADIK ENEQSLLEYL EKQRSRIGCR
TIVYWGIGRN RYQLEIPENF TTRNLPEEYE LKSTKKGCKR YWTKTIEKKL ANLINAEERR
DVSLKDCMRR LFYNFDKNYK NWQAAVECIA VLDVLLCLAN YSRGGDGPMC RPVVLLPKED
TPVFLDLKGS RHPCITKTFF GDDFIPNDIL IGCEEKEEEN GKASCVLVTG PNMGGKSTLM
RQAGLLAVIA QMGCYVPAEV CRLTPIDRVF TRLGASDRIM SGESTFFVEL SETASILTHA
TAHSLVLVDE LGRGTATFDG TAIASAVVKE LAENIKCRTL FSTHYHSLVE DYSQNVAVRL
GHMACMVENE CEDPSQETIT FLYKFIKGAC PKSYGFNAAR LANLPEEVIQ KGHRKAREFE
KTTHSLRLFR EVCLASERST LDAEAVHKLL TLIDEL
//
