ID S7PHL8_MYOBR Unreviewed; 2620 AA.
AC S7PHL8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=D623_10026736 {ECO:0000313|EMBL:EPQ07587.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ07587.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KE162248; EPQ07587.1; -; Genomic_DNA.
DR eggNOG; KOG0584; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14030; STKc_WNK1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF46; SERINE_THREONINE-PROTEIN KINASE WNK1; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EPQ07587.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 222..480
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1698..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1781..1802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2058..2087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2107..2178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2201..2307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2350..2484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1358
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2371..2482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2620 AA; 276775 MW; 6D93572BEC7529A8 CRC64;
MSGGAAEKQG GTPSSLFLSP PAPTPKNGSS SDSSVGEKLG AAGTDAGTGR TEEYRRRRHT
MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL SLPQPTVAAV VPQSTPPEPH
REETLTATVA AQVAQQPSAA VAAPREPAAP GPAASTAPSS ISKDRQIAQP DHVGSKEEPP
SARSGSGGSS AKESQEERSQ QQDDIEELET KAVGMSNDGR FLKFDIEIGR GSFKTVYKGL
DTETTVEVAW CELQDRKLTK SERQRFKEEA EMLKGLQHPN IVRFYDSWES TVKGKKCIVL
VTELMTSGTL KTYLKRFKVM KIKVLRSWCR QILKGLQFLH TRTPPIIHRD LKCDNIFITG
PTGSVKIGDL GLATLKRASF AKSVIGTPEF MAPEMYEEKY DESVDVYAFG MCMLEMATSE
YPYSECQNAA QIYRRVTSGV KPASFDKVAI PEVKEIIEGC IRQNKDERYS IKDLLNHAFF
QEETGVRVEL AEEDDGEKIA IKLWLRIEDI KKLKGKYKDN EAIEFSFDLD RDVPEDVAQE
MVESGYVCEG DHKTMAKAIK DRVSLIKRKR EQRQLVREEQ EKRKQEESSF KQQVDQQSSA
SQAGIKQLPS ASTGIPTAAT TSASVSTQVE PEEPEADQHQ QLQYQQPSIS VLSDGTVDSG
QGSSVFTESR VSSQQTVSYG SQHEQAHSTG TLPGHTASVV QAQSQPHGVY PPSSMPRRGR
SMSVCVPHLS AVPSLSRISP SAPSTPPPVQ SAPLSPPLLR TAPEETFAEK LCKALESVLP
MHSASQRKHR RSSLPSLFVS TVAISQRRKS TSFLEAQTHH FQPLLRTVGQ NLLPPGGSPA
NWTPEAVVML GTTASRITGE PCEIPVNPLF EPPQVYSDCR PGLVLSEEAH SFVPQEALYL
AGVQYQAQVA EQYEGIPYNS PVLSSPMKQI PEQKPVQGGP TSRSVFEFPS GQAFLAQGQS
QGQPSSSIVT GVSSSQPIQH SQQQQGIQQT APPQQTVQYS LPQTTTSSEA TTAQPVSQPQ
ASQVLPQVSA GKQLPVSQPV PTIQGEPQIS VATQPSVVPV HSGAHFLPMG QPLPTSLLPQ
YSVSQIPISA PHVSAAQTGF STLPITIAAG INQPLLTLAS SATASVIPGG STLASSQLPT
LLQPVTQLPS QVHPQLLQPA VQSMGLPANL GQAAEVPLPS GDVLYQGFPP RLPLQYPGDS
NIAPSSSVAS VCIPSTVLSP PMPTEALATP GYFPTVVQPY MESNLVVPVG SIGGQVQVSQ
PAVSLAQAPT TSSQQAALES TQGVSQVAPP EPVPITQPQP TQPTTLVSSI DSAHSDVASG
MSDGNENVPS SSGRHEGRTA KRHYRKSVRS RSRHEKTSRP KLRILNVSNK GDRVVECQLE
THNRKMVTFK FDLDGDNPEE IATIMVNNDF ILATERESFV DQVREIIEKA DEMLSEDVSV
EPEGDQGLES LQGKDDYGFS DSQKLEGEFK QPLPASSMTQ QIGIPTSSLT QVVHSAGRRF
IVSPVPESRL RESKVFTGEI SDTVAASTSH GAGMNLSHSA SSLSLQQAFS ELKNAQMTEG
PNTAPPNFSQ TGPTFPVVPP SMGSIAGVPT TAATTLSVSV PVTSCPLNDI STSVIQSEIT
VPTEKGITTC TSVTSSELCI PPVSEESPVL SSMVSGITIP AVVSTSATSQ SVLAPTSGSV
VSSIGTLPSR PVSTTSASAV SSAAAPGANP PPALSQPSAG STTTGAATLT SVSNTTPFPS
IASQPSLQLS SSTSAPTLAE TVVVSAHSLD KISHSSTAGL ALSHSAPSSS SSPGAAVSSS
ISQPGGVHPL VIPSVIASTP VLAQAAGPTS TPLLPQIPTI PPLAQPVASV PAVQQTLIHS
QPQPALLPNQ PHTHCPEIDA DTQPKAPGID DIKTLEEKLR SLFSEHSSSG TQHASVSLET
SLVVETNATP GIPTTAVAPS KLMTSTTSTC LPPTSLPLGT TGLPVIPVVT PGQVSTSVSY
VSAPVSTTPG VKPATAPSKL PLTKAPVVSV GSELLAGIPS SEQLPPFPGP SQTQQPLEDL
DAQLRRALSP ETIAVTSAVG PGSMVPPTAV TEAGAQPQKD VSQVTAASSG TGVFKTGRFQ
VSVAMDDAQK EGKNKSEDAK SVRFESSTSE SSVLSSSSPE STLVKPEPNG MTIPDISSDM
PDGAHKTPAS EAKSEIGQPT KVGRFQVTTT ANQVGRFSVS RTEDKVTEAK KEGPMASPFM
DLEQTVLPAA IPKKEKPELS DPSHLNGPSS DLEAAFLSRD VDDGSGSPHS PPQLSSRSLP
IQNLSQSLSN SLNSSYMSSD NESDIEDEDL KLELRRLREK HLKEIQDLQS RQKHEIESLY
TKLGKVPPAV IIPPAAPLSG RRRRPTKSKG SKSSRISSLG SKSPQLSGNL SGQSAASGLH
PQQTLQPPGN IPETGQNQLL QPLKPSPSSD NLYSAFTSDG AISVPSLSAP GQGTSSTNTV
GGTVNSQAAQ TQPPAMTSSR KGTFTDDLHK LVDNWARDAM NLSGRRGSKG HMNYEGPGMA
RKFSAPGQLC ISMTSNLAGP APISAASATS LGHFTKSMCP PQQYSFPAPP FGTQWSGTGG
PAPQPLGQFQ PVGTASLQNF NISNLQKSIS NPPGSNLRTT
//
