ID S7PLQ6_MYOBR Unreviewed; 1738 AA.
AC S7PLQ6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 5 {ECO:0000313|EMBL:EPQ09042.1};
GN ORFNames=D623_10034408 {ECO:0000313|EMBL:EPQ09042.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09042.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; KE162617; EPQ09042.1; -; Genomic_DNA.
DR MEROPS; S08.076; -.
DR eggNOG; KOG3525; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 14.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 14.
DR SMART; SM01411; Ephrin_rec_like; 6.
DR SMART; SM00261; FU; 22.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 8.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 1624..1644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 312..452
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 22
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 63
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 237
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1738 AA; 192551 MW; 449DB4BF45F70E6A CRC64;
MNIEGAWKRG YTGKNVVVTI LDDGIERTHP DLMQNYDALA SCDVNGNDLD PMPRYDASNE
NKHGTRCAGE VAAAANNSHC TVGIAFNAKI GGVRMLDGDV TDMVEAKSVS FNPQHVHIYS
ASWGPDDDGK TVDGPAPLTR QAFENGVRMG RRGLGSVFVW ASGNGGRSKD HCSCDGYTNS
IYTISISSTA ESGKKPWYLE ECSSTLATTY SSGESYDKKI ITTDLRQRCT DNHTGTSASA
PMAAGIIALA LEANPFLTWR DVQHVIVRTS RAGHLNANDW KTNAAGFKVS HLYGFGLMDA
EAMVMEAEKW TTVPQQHVCV ESTDRQIKTI RPNSAVRSIY KASGCSDNPN HHVNYLEHVV
VRITITHPRR GDLAIYLTSP SGTRSQLLAN RLFDHSMEGF KNWEFMTIHC WGERAAGDWI
LEVYDTPSQL RNFKTPGKLK EWSLVLYGTS VQPYSPTNEF PKVERVRYSR VEDPTDDYGT
EDYAGPCDPE CSEVGCDGPG PDHCNDCLHY YYKLKNNTRV CVSSCPAGHY HADKKRCRKC
PPNCESCFGS HGDQCLSCKH GYFLNEETNS CVPHCPDGSY QDTKKNICRK CSESCKTCTD
SHNCTECRDG LSLQGSRCSI ACENGQYFNG QDCQPCHRFC ATCAGAGADG CINCTEGYFM
EDGRCVQSCS ISYYFDHSSE NGYKSCKKCD TSCLTCNGPG FKNCTSCPSG YLLDLGMCQM
GTICKDGEYI DEHGHCQICE ASCAKCWGPT QENCLDCPVT RVLDDGRCVL DCPSGKFALK
NQCHLCHYTC QECQGNEPSN CTSCGVDKQG QQRFLYWGEC RESCPVGHYP AEEHVCLPCP
DNCELCHSAD ICTRCTNGYF IASTNHTCQK LECGPGEVQD PDLGECVPCE EGCLGCSLDD
PGTCTSCVTR YYMFEHHCYK SCPEKTYTEK FECKACTANC DICDQNGCYW CEEGFFLRGG
SCVRKCGPGS YSDTETGSCE PCHRACETCT GLGHDECSSC PPGLQLLHGT CVAPTQTQTE
GKFWNEPVLT SSPSLVKSLL QKQRRWKFQI KRDVLRKQQP CHSSCKTCNG SERLCTSCPK
GTYLLAQACV AACPEGTWPS VRSGSCENCT EACASCSGAD LCDKCQTQLE HPLFLHEGRC
YTGCPEGFYA EEGICKRCSS PCRKCEGNAT NCQACEGGLV LDQGVCQETC SERHVAVEGV
CKHCPEMCQE CIHEKTCKEC MPAFFLHEDM CHQSCPQQFY KDEDAHQCLP CHKDCLECSG
PSADNCNLCA KYFSVLYDGQ CLGNCPARTY YKRKTNECKD CPSSCQTCSS PGTCTSCLEG
LRLNSHGDCE PHKECAPSEY WDEEALGCKP CHTKCFRCTG PSEDQCHTCP RDSLLLNMTC
VQDCPEGYYT DEDSHRCDPC HSSCRTCEGR HSTQCLSCPP GWFQLGKECL PQCREGYYAA
NSTGRCERCN KSCKACRGPR PTDCLSCDTF FFLLHSKGEC RRTCPDHYYA DQKTQTCERC
HPTCHECKGK GALQCLSCVW SYHLAGGICT SDCLVGEYRV GEGEKFNCEK CHESCIECKG
PGAKNCTMCP ANLLLVMDDS RCLHCCNTSD PTDTQDCCDC QNTTDECILP ASEIGSAPEH
SKTALFITSF IMLVLLIGAA VIVWRKSRGR AQPVEKGYEK LADPSKSYSS YKSNYRESTN
FEEDQVIEYR DRDFDEDDED DIVYMGQDGT VYRKFKYGLL DDDEEDELEY DDESYSYQ
//
