ID S7PM74_MYOBR Unreviewed; 828 AA.
AC S7PM74;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Transmembrane protease serine 11F {ECO:0000313|EMBL:EPQ09382.1};
GN ORFNames=D623_10028095 {ECO:0000313|EMBL:EPQ09382.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09382.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; KE162718; EPQ09382.1; -; Genomic_DNA.
DR AlphaFoldDB; S7PM74; -.
DR MEROPS; S01.321; -.
DR eggNOG; KOG3627; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 2.
DR Gene3D; 3.30.70.960; SEA domain; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 4.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF12; LOW QUALITY PROTEIN: TRANSMEMBRANE PROTEASE SERINE 6; 1.
DR Pfam; PF01390; SEA; 2.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00200; SEA; 2.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 2.
DR PROSITE; PS00135; TRYPSIN_SER; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:EPQ09382.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EPQ09382.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..176
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 207..453
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 457..574
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 597..827
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 828 AA; 93636 MW; 04A2547EF01712F5 CRC64;
MSHRPAQFSK ADNYPPVEFQ RRQQFWDPIR LALFTLVIVA IIGITIGIVS HYVVEDDKSF
YYLASFQVTN VKYRENYGIK TSKEFTQRSH QIERMMSRIF RRSSGAGRFI KSHVIKISPD
ENGVNILMVL MFRYPSTSSA EYIRKIIERI LYQSLKTKEM PLTINKPSLT LTSIDSKKMR
NLLNSRCGIR MTSSNMPLPA YTSTERIVQG RETAMEGEWP WQASLQLKGA GHQCGASLIS
NTWLLTAAHC FRKNKDPRQW IATFGTTINP PAVERNVGKI ILHENYHRET NENDIALAQL
TTRVEFSNVV QRVCLPDSSI KLPPKTSVFV TGFGSIVDDG PTQNKLRQAR VETISSDVCN
RKDVYDGLIT SGMLCAGFME GKVDACKGDS GGPLVYDNHD IWYLIGISAY RSERMPGCYS
FDEKSQSSTE VEECAFSTVY DVSDLYWLVY TIINQKKVHY FQTSFQIPSI EYNPDFSVEH
SKIRNDLKQK INDEIDKIFQ NSSLNHHYIE SHVVNFRSSD DGLKTDVLLK FHFLPNNAET
VKSQAANILH QKLKLNESFL KIDTSLPYLK DINKIQAEHI LNSGCGLGRE SPSMEKIANG
YIAKKADWPW QASLQMDGTH YCGASLISEE WLLTAAHCFD TYKNPKLWTA SFGTTLSPPL
MRRRVQSIVL HENYAAHKHE DDIALVKLSA PVLFSEDVHR VCLPDAAFEV LPKSKVFVTG
WGALKVNGPF PNTLRQVEVE IISNDRCNEV HVYGGAVSSG MICAGFLEGK LDACEGDSGG
PLVVARDRNI WYIIGIVSWG IDCGKENNPG IYTKVTHYRD WIKSKTTI
//
