ID S7PNJ3_MYOBR Unreviewed; 664 AA.
AC S7PNJ3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Neurofilament heavy polypeptide {ECO:0000313|EMBL:EPQ09907.1};
GN ORFNames=D623_10027521 {ECO:0000313|EMBL:EPQ09907.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09907.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KE162863; EPQ09907.1; -; Genomic_DNA.
DR AlphaFoldDB; S7PNJ3; -.
DR eggNOG; ENOG502QYDU; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR InterPro; IPR010790; DUF1388.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF07142; DUF1388; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 42..165
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 49..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 214..246
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 73402 MW; 3FAD0516A8264257 CRC64;
MCTRGSPPAH SRNPLPPDLP SRRGALPTPR GFPSVQSTLQ SEEWFRVRLD RLSEAAKVNT
DAMRSAQEEI SEYRRQLQAR TTELEALKST KDSLERQRSE LEDRHQTDIA SYQDAIQQLD
AELRNTKWEM AAQLREYQDL LNVKMALDIE IAAYRKLLEG EECRIGFGPS PFSLPEGLPK
MPSTATHIKV KSEEKIRVVE KSEKETVIVE EQTEEIQVTE EVTEEEEKEA KEEEGEDEEQ
GEEEEAEGGE ATKRGCIEEE ERGEEEEAEG GEEATKSPPA EEAASPEEEA KSPEKEEAKS
PAKTPMKEEA KSPAEVKSPE QAKSPAKEEA KSPTEVKSPE KAKSPVKEEA KSPAKEEAKS
PNEVKSPVKE EAKSPPEVKS PEKAKSPVKE EAKSPEKAKT LDVKSPGAKT PVKEEVRSPA
DIKSPVKPKS PGKEEVKSPE KVKSPVKEEA KAPEKVSKKE EAKSPMKEDE KPQEVKVKEP
PKKVEEEKAP ATPKTEKDSK KDEVPKKEAP KPEVQEKPKE PVAEAKKEEA EGKKKAATPE
KEAPAKEKEE AKAKEKTEVD KKEPGDAKAK GPSKAAEKGP EKPKKEETLA APEKKDAKEE
KATEAKKPEE KPKPEARAKE EPSKEAPAPS KAKTEKAEKS SSTDHKDSRP PEKATGDKAA
QGEK
//
