ID S7PQB8_MYOBR Unreviewed; 2061 AA.
AC S7PQB8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Dynein heavy chain 5, axonemal {ECO:0000313|EMBL:EPQ10652.1};
GN ORFNames=D623_10029790 {ECO:0000313|EMBL:EPQ10652.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ10652.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE163046; EPQ10652.1; -; Genomic_DNA.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF14; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 207..292
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 363..623
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 639..982
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1012..1232
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1478..1586
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1618..1757
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 1766..2058
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 647..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 867..922
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1173..1200
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2061 AA; 236487 MW; FD3DA7A0335A9753 CRC64;
MHLLGWFPTH LHFDFCFLLK EHPLETLPFL LLADRGPWGT NTRNYHLYKA NDGGDFTASW
AFNIQIRTVE SYVDKRMGTT YGPPAGKKMT VFIDDVNMPI INEWGDQVTN EIVRQLMEQS
GFYNLEKPGE FTSIVDIQLL AAMIHPGGGR NDIPQRLKRQ FSIFNCTLPS DASMDKIFGV
IGTGYYCMQR GFSEEVRDSV TKLVPLTRRL WQMTKMKMLP TPAKFHYVFN LRDLSRIWQG
MLNTTSEVIK EPDELLRLWK HECKRVIADR FTVSDDVTWF DKALVSLVEE AFGEEKKLLV
DCGIDAYFVD FLRDAPELTG ETSEEADTEM PKVYEPIESF DHLKERLNMF LQLYNESVRG
AGMDLVFFED AMVHLVKISR IIRTPRGNAL LVGVGGSGKQ SLTRLASFIA GYTFFQITLT
RSYNTSNLME DLKILYRTAG QQGKGITFIF TDSEIKDESF LEYMNNVLSS GEVSNLFARD
EVDEINSDLI PVMKREHPRR PPTNENLYEY FMSRVRQNLH IVLCFSPVGE KFRNRALKFP
ALISGCTVDW FSRWPKDALI AVSEHFLSSY DIDCSLKTKK EVVQCMGSFQ DGVAEKCVDY
FQRFRRSTHV TPKSYLSFIQ GYKFIYGEKH VEVQTLANRM NTGLKKLKEA SESVAALSKE
LEVKEKELQV ANYKADTVLK EVTMKAQAAE KVKAEVQKVK DKAQAIVDGI SKDKAIAEEK
LEAAKPALEE AEAALQTIKP SDIATVRTLG RPPHLIMRIM DCVLLLFQRK VNAVKIDPEK
SCTIPSWQES LKLMTAGNFL QNLQQFPKDT INEEVIEFLG PYFEMADYNI ETAKRVCGNV
AGLCSWTKAM ASFFSINREV LPLKANLVVQ ENRYVVAMQD LQKAQAELDD KQAELDVVQA
EYEQAMTEKQ TLLEDAERCR RKMQTASALI GGLAGEKERW TEQSKEFAAQ TKRLVGDVLL
ATAFLSYSGP FNQEFRNLML NDWQKEMKAR EIPFADNLNL NEMLIDAPTI SEWNLQGLPN
DDLSIQNGII VTKASRYPLL IDPQTQGKIW IKNKESQNEL QITSLNHKYF RNHLEDSLSL
GRPLLIEDVG EELDPALENV LERNFIKTGS TFKVKVSDKE VDVMHGFRLY ITTKLPNPAY
TPEISARTSI IDFTVTMKGL EDQLLGRVIL TEKQELEKER THLMEDVTAN KRRMKELEDN
LLYRLTSTQG SLVEDEGLII VLSNTKKTAE EVTQKLEISA DTEIQINSAR EEYRPVATRG
SILYFLITEM RLVNEMYQTS LRQFLGLFDL SLARSVKSPI TSKRIANIIE HMTYEVYKYA
ARGLYEEHKF LFTLLLTLKI DIQRNWVKHE EFLTLIKGGA SLDLKACPPK PAKWILDMTW
LNLVELSKLR QFSDVLDQIS RNEKMWKIWF DKENPEEEPL PNAYDKSLDC FRRLLLIRSW
CPDRTIAQAR KYIMDSMGEN YAEGVILDLE KTWEESDPRT PLICLLSMGS DPTDSIIALG
KRLKIETRYV SMGQGQEVHA RKLLQQTMAN GGWALLQNCH LGLDFMDELM DMVTETEMVH
AAFRLWMTTE VHKQFPITLL QMAIKFANEP PQGLRAGLKR TYGGVSQDLL DVSTVAQWKP
MLYAVAFLHS TVQERRKFGP LGWNIPYEFN QADFNATVQF IQNHLDDMDI KKGVSWSTVR
YMIGEIQYGG RVTDDYDKRL LNTFAKVWFS ENMFAPDFSF YQGYNIPKCS TVDNYLHYIQ
SLPTYDSPEV FGLHPNADIT YQSKLAKDVL DTILGIQPKD SSGGGDETRE AVVARLADDM
LEKLPPDYGP FEVRERLQKM GAFQPMNIFL RQEIDRMQRV LTLVRSTLTE LKLAIDGTII
MSENLRDALN CMFDARIPAQ WKKASWVSST LGFWFTELLE RNCQFTSWVF NGRPHCFWMT
GFFNPQGFLT AMRQEITRAN KGWALDNMVL CNEVTKWMKD DIAAPPTEGV YVYGLYLEGA
GWDKRNMKLI ESKPKVLFEL MPVIRIYAEN NTLRDPRFYS CPIYKKPVRT DLNYIAAVDL
RTAQTPEHWV LRGVALLCDV K
//