ID   S7PW87_MYOBR            Unreviewed;       907 AA.
AC   S7PW87;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Toll-like receptor 12 {ECO:0000313|EMBL:EPQ15238.1};
GN   ORFNames=D623_10012412 {ECO:0000313|EMBL:EPQ15238.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15238.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE164119; EPQ15238.1; -; Genomic_DNA.
DR   RefSeq; XP_005878466.1; XM_005878404.2.
DR   AlphaFoldDB; S7PW87; -.
DR   GeneID; 102258164; -.
DR   KEGG; myb:102258164; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG4641; Eukaryota.
DR   OrthoDB; 1207361at2759; -.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF13676; TIR_2; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EPQ15238.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..907
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004555767"
FT   DOMAIN          758..901
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   907 AA;  99760 MW;  61CBE4DBEED21B49 CRC64;
     MGGRLLLPGL LLFPPLISGW TISNCLVTEG SRLHLVSHFF LCGLDSRLPL LAVCSGVTNV
     TKAVEAVPQG VEGLCLRGSP PVLPADAFSR FPGLKALGLT LYLTQILPGA FRGLGQLQRL
     SFMHLPVKDL FLPPEALGNL SSLQYLAFSG VCLDGNSGVR LPPNLRRLSV TLSCLEDMGQ
     LADIFPDLVL GSSSGDAWTL ETLDLRSNRW LKMASPGGLQ GLKLGTLNLD HTKMKAAAVM
     GLGLRRLDAL SVTYTDTAEL PAGTVAHFEL QELNLGQGRM RIEHIALEAL ASCESLKSLS
     LKGSGLMDLP PGFLAALPRL QRLNLSGNKL RSAVLCPNET GAVSGLRALD LSSNELRSLA
     PDTFSCLSHL RELLLQTNQL VWLEGQVFQG LRRLEMLDLS NNPLEALGKG WLAPLPALTT
     LNLLKTHIVL SPAWDFWGLE SLQDLRLPLR SGPSGTALSL PTRLTSLELH AVPGGELWEL
     ASPVFPALQN LTLNGWGLQL GTEKVPKIFP ALRQLSLFGS SLEGLCSPDT PSVFLWQLPR
     LQYLRVQGDG RGPRPCCITG LPSLQELTLQ RLLSRAQPRR VQLEELVGDL PRLQVLHVAR
     TGLETLSAVA FQGLGSLQVL VLDWEAGLVL DGSLQEHSPQ MPQYVYVLGS SLACQCANAW
     VEPWLERSPR TYVHIESAQL CQPEAGVHPK QRLFPFLWSH CPRTLELGLF LGSSALLLLL
     ISLPLLQEAR NSWLLYLQAL FRAWLQDLRG PKGEGKRFLY DVFVSHCRQD QAWVVQELLP
     ALEGRRGLRL CLPERDFEPG KDVADNVVES MANSQVTLCV LSGQALHTPR CRLELRLATS
     LLLAAPRPPL LLLLVFLERV SRHQLPGYHR LARLLRRGDY CVWPKEEEGK DDFWAWLGSR
     LEQARRG
//