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Database: UniProt
Entry: S7Q1X6_GLOTA
LinkDB: S7Q1X6_GLOTA
Original site: S7Q1X6_GLOTA 
ID   S7Q1X6_GLOTA            Unreviewed;       838 AA.
AC   S7Q1X6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   03-JUL-2019, entry version 37.
DE   SubName: Full=Urease {ECO:0000313|EMBL:EPQ54001.1};
DE   Flags: Fragment;
GN   ORFNames=GLOTRDRAFT_62463 {ECO:0000313|EMBL:EPQ54001.1};
OS   Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617)
OS   (Brown rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX   NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ54001.1, ECO:0000313|Proteomes:UP000030669};
RN   [1] {ECO:0000313|EMBL:EPQ54001.1, ECO:0000313|Proteomes:UP000030669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ54001.1,
RC   ECO:0000313|Proteomes:UP000030669};
RX   PubMed=22745431; DOI=10.1126/science.1221748;
RA   Floudas D., Binder M., Riley R., Barry K., Blanchette R.A.,
RA   Henrissat B., Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S.,
RA   Aerts A., Benoit I., Boyd A., Carlson A., Copeland A., Coutinho P.M.,
RA   de Vries R.P., Ferreira P., Findley K., Foster B., Gaskell J.,
RA   Glotzer D., Gorecki P., Heitman J., Hesse C., Hori C., Igarashi K.,
RA   Jurgens J.A., Kallen N., Kersten P., Kohler A., Kues U., Kumar T.K.,
RA   Kuo A., LaButti K., Larrondo L.F., Lindquist E., Ling A., Lombard V.,
RA   Lucas S., Lundell T., Martin R., McLaughlin D.J., Morgenstern I.,
RA   Morin E., Murat C., Nagy L.G., Nolan M., Ohm R.A., Patyshakuliyeva A.,
RA   Rokas A., Ruiz-Duenas F.J., Sabat G., Salamov A., Samejima M.,
RA   Schmutz J., Slot J.C., St John F., Stenlid J., Sun H., Sun S.,
RA   Syed K., Tsang A., Wiebenga A., Young D., Pisabarro A., Eastwood D.C.,
RA   Martin F., Cullen D., Grigoriev I.V., Hibbett D.S.;
RT   "The Paleozoic origin of enzymatic lignin decomposition reconstructed
RT   from 31 fungal genomes.";
RL   Science 336:1715-1719(2012).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
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DR   EMBL; KB469304; EPQ54001.1; -; Genomic_DNA.
DR   RefSeq; XP_007867358.1; XM_007869167.1.
DR   STRING; 104355.XP_007867358.1; -.
DR   EnsemblFungi; EPQ54001; EPQ54001; GLOTRDRAFT_62463.
DR   GeneID; 19307480; -.
DR   KEGG; gtr:GLOTRDRAFT_62463; -.
DR   KO; K01427; -.
DR   OrthoDB; 183108at2759; -.
DR   Proteomes; UP000030669; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030669};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030669}.
FT   DOMAIN      398    838       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    589    589       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       403    403       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       405    405       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       486    486       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       486    486       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       515    515       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       541    541       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       629    629       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     488    488       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     486    486       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
FT   NON_TER     838    838       {ECO:0000313|EMBL:EPQ54001.1}.
SQ   SEQUENCE   838 AA;  89965 MW;  8C50E5E69863B91B CRC64;
     MHLLPREEAK LLLHQAGFLA QKRLARGLKL NQTEATALIA SQLQERIRDG QHSVAELMQH
     GKTLLGRRHV LPSVPGLLHE IQVEGTFQDG VFLVTVHDPI CTEDGDLAAA LYGSFLPVPP
     NEKFPVADES EYAKEKAPGA VIVKKERIVI NKGRERVKLK VTNNGDRPIQ IGSHYHFIET
     NASLSFDRAK AYGKRLDIAA GTAVRFEPGD SKTVTLCAIA GAQIISGGNL LASGIVDADR
     TDEIVRNLVQ KGFGHVPEPG AAEVHEDTDI GRQAYVAMYG PTVGDKVRLG DTALWIEVER
     DETVYGDEVK FGGGKSIREG MGQATNRPAS ECLDLVITNA LIVDWSGIYK ADIGVKDGVI
     TGIGKAGNPD VMAHVHPALT IGSSTEVIAG EKLILTAGAV DAHVHYICPQ QVYEALAAGT
     TTMIGGGTGP SAGTNATTCT PSPFYMRHML AATDGLPMNF AFTGKGNDAG PQALEDIVRA
     GAAGLKLHED WGSTPAATMN CLDVGDKYDV QVNIHTDTLN ESGFVESTIA AFGNRTIHTY
     HTEGAGGGHA PDIIVVCGQE NVLPSSTNPT RPYTNNTLDE HLDMLMVCHH LDKSIPEDLA
     FAESRIRGET VAAEDVLQDM GAISMISSDS QAMGRVGEVV SRTWRTASKM REFRGPLASL
     GDSEGRDNAR VKRYIAKYTI NPAITHGISH LIGHVAVGTL ADLVLWKPEN FGAKPEMILK
     SGVIAWSQMG DANASIPTVQ PFYSKPMWGS YPASAALNSV AFVSEISLTS GVIKSYGLSK
     RFEAVKNCRN VKKGDMKWND AVPKMSVDPE SYEVRADGEL ADVAPAERLP LARTYNLF
//
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