ID S7Q5J2_GLOTA Unreviewed; 575 AA.
AC S7Q5J2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=GLOTRDRAFT_116543 {ECO:0000313|EMBL:EPQ54753.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ54753.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ54753.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ54753.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; KB469303; EPQ54753.1; -; Genomic_DNA.
DR RefSeq; XP_007867005.1; XM_007868814.1.
DR AlphaFoldDB; S7Q5J2; -.
DR STRING; 670483.S7Q5J2; -.
DR GeneID; 19300197; -.
DR KEGG; gtr:GLOTRDRAFT_116543; -.
DR eggNOG; KOG1625; Eukaryota.
DR HOGENOM; CLU_014923_2_1_1; -.
DR OMA; PFLDIEH; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 2.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669}.
FT DOMAIN 28..115
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 150..193
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 309..530
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 103..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 62554 MW; A52C1255ECA7CD44 CRC64;
MAIDFSSSTE LRIELLQYFQ HNELAEEDLL SECIKLCQNF HITPENVYYK WEALNFNTGR
SVNLFTMDSV NQIKAAIQQD LAKEQAKKAR AQLSGRMTRG RAPVLGLPGR MGTPVKRSTV
GGAQSSGAGA SVAGPSKVKF VGPSSDPAAV KKRAYRYMYE KISERSEVLD DRIDDFAELI
RTYYSISEFG DPGSSTDEET TIVGRIVPDA ESLSTKLNDA SVVLETSKML GSGARVPLRF
DPSLKITASP SGGELAGIGL FPGAIVAMRG RNGGGGYFLV TEILNLPPLR TRPVDEASET
SGGDDPGSVF IACGPYTPDT DLGYKPWTDL LKKIKAKKPD VLILLGPFIS TDHPYIRQGL
ASSPPAELFR DTFLAPLAEF LASAPGSAVV LVPSVKDIIS DHAVFPQAEL PASLMSDPRI
HLAPNPARFS LNGITFGAST VDVLFHLRKE EYFKRSLTPV DQPQDAMSSL CRHVLQQHSF
YPIFPAPHEL AHDVNLDVSH SAGLALDAEC AEAAAPDVLI LPSRLKHFSK VVEDTVAINP
TFLTKGIYAE MRLPARRTAG LKDEILKRNV MKLEE
//
