ID S7Q776_MYOBR Unreviewed; 5672 AA.
AC S7Q776;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Nesprin-1 {ECO:0000313|EMBL:EPQ19233.1};
GN ORFNames=D623_10021326 {ECO:0000313|EMBL:EPQ19233.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19233.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
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DR EMBL; KE164616; EPQ19233.1; -; Genomic_DNA.
DR eggNOG; KOG0516; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd21243; CH_SYNE1_rpt2; 1.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.60; -; 21.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR047291; CH_SYNE1_rpt2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524:SF5; KLARSICHT PROTEIN; 1.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 6.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 27.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 28.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..78
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 122..227
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1230..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1258..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1357..1391
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1937..1991
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2299..2333
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2566..2593
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3592..3619
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4366..4396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5159..5217
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 5672 AA; 647852 MW; 731952F63B23C65D CRC64;
MKDGVKLLAL LEVLSGQKLP CEQGRRMKRI HAVANIGTAL KFLEGRRIKL VNINSTDIAD
GRPSIVLGLV WTIILYFQIE ELTSNLPQLQ TLSSSTSSVD STVSSEAASP PSKRKVATKI
QGNAKKALLK WVQYTAAKQT GIEIKDFGRS WRNGVAFHSV IHAIRPELVD LERVKGRSNR
ENLEEAFTIA ETELGIPRLL DPEDVDVDKP DEKSIMTYVA QFLKHYPDVH NTGTDGLEND
EIFPDFLLFA NSIQNLKRED RLMLKETKVW IEQFERDLTR AQMTEANLQD KYQSFKHFRV
QYEMKRKQIE HLIQPLQRDG KLSLDQALVK QSWDRVSSRL FDWHIQLDKS LPAPLGTIGA
WLYRAEVALR EEITTQQVHE ETANTIQRKR EQHKDLLQNT DAHKRAFHEI YRTRSVNGIP
VPPDQLEDMA ERFHFVSSTS ELHLMKMEFL ELKYRLLSLL VLAESKLKSW IIKYGRRDSV
ELLLQNYITF IENSKFFEQY EVTYQILKQT AEMYVKADGS VEEAENVMKF MNETTAQWRN
LSVEVRSVRS MLEEVIANWD RYGDTVAGLQ AWLEDAEKML SQSELAKKDF FRNLPHWIQQ
HSAMNDAGNF LIETCDEVVS RDLKQQLLLL NGRWRELFME VKQYARADEV DRMKREYTDG
VTALSDFATE AHRKLSEPLE VSFINVKLLI QDLEDIEQRI PVMDAQYKIL TKTAHLVTKE
SSQEEAKEMF ATMSGLKEQL TKVKERYSPL LYESQQLSVL LEELEKQMTL FYDSLGKISE
IITVLEHEAQ SSALFKQKHQ ELLACQESCK KAMAHIEKGS QSVQKFVTLS HVLKHFDQTK
LQRKTAEVHV AFQNMVKKTG DWKKHVETNS RLMKKFEESR AELEKVLRVA QEGLEEKGDP
EELLRRHTEF YGQLDQRVLN AFLKACDDLT DILPEQEQAG LQEAVRKLHK QWKDLQGEAP
YHLLHLKIKV EENKFLACVE ECRAELARET KLVPQEGSEK MIKEHRIFFS DKGPHHLCEK
RLQLIEELCL KLPGRDPVRD TPGACQATLK ELRAAIESTY TQLAEDPDKW KDYTSRISEF
SSWIAAKETQ LKGIKKEAID TANHGEVKRA VEEIRNGVTQ KGETLSWLKS RLQVLIEVSS
EKEAQKQGDE LAKVSSSFKA LTALLSEVEK MLSSFGDCVQ YKEIVKSSLK ELISGSKEVQ
EQAEEILDTE NLFEAQQLLL HHQQKTKRIS AKKRDVQQQM TQAGQGEGGL PGPVQEELRK
LESTLDGLER SRERQERRIQ VTLRKWERFE TNKETVVRYL FQTGSSHERF LSFSSLESLS
SELEQTKEFS KRTEGIAVQA ESLVKEASEI PLGPKNKQLL QQQAKSIKEQ VKKLEDTLEE
DIKTMEMVKN KWEHFGNNFE TLSVWITEKE KALNALETSP SAMDMQTNQI KVTIQEIESK
IGSITGLEEE AQSFAQFITT GESARIKAKL TQLRRYWEEL REHAQGLEGT ILGQVSQQQK
FEENLRKAQQ SVSEFEDKLA DPIKTCSSAT ETYKALQEHM DLCQALESLS SALAALSAGA
QKVVSRGCSV QEAAALQQRY QGLLSRAKER QTALENLLAH WQRLEKELST FLTWLERCKA
IASSPEVDVT ADRVKVESEL QLTQASSRKC GANDTLFALQ SEVVSQASNY SNLVQLKESL
FSVASKDDVK TMKLHLEQLD ERWRVLPQIL SKRLHFLQSV VAEHQQFDEL LLSFSVWIKQ
FLGELQATSE ISLMDHQAAV TRHKDHAAEV ESKRGELQSL QGHLAKLGAL GRAEDLHVLQ
GKAEDCFQLF EEAGQVVERR QLALAQLAGF LQSHTSLSEA LHRLRQTVEA TNSMNKKQTD
LLEKDLHDAI QDVKTLESTA IALDGILTKA QYHLKCGSSE QRTSCRTSAD HLCLELERIQ
NLLGTKQSEA DALAALKKAF HDQKEELLKS IEDIEERADK ERLKEPTRQA LQQRLRVFNQ
LEDELNSHEH ELCWLKDKAK QIAQKDVAFA PKVDTEINRL EVTWDDTKKL IHENQGQCCG
LIDLMRDYQN LKSAVSKVLE HASNVIATRT TIKDEEDLKW ALSKHETARN EICKEQKELD
DFTSKGKQLL SELKKIHSSD FILVKTDMES TMDRWLDVSE RIEENMDRLR VSLSLWADIL
SSKDEIEGWS NSSVPQLAES ISNLNNSLRT EEFLKEFESE VRNNALKLED LHAKVNDLKE
LTKNPETPSD LQFIEADLRQ KLEHAKEITE DAKGTLKDFR AQSTQVEKFI NDITTWLAKL
EESLVNCAQT ETCEGLKKVK EMQKELQSQQ SNISSTQENL NSLCRKYHSA ELERLGGAMT
GLTKKHEAAS QLCSRTQASL QDSLEKHFHE SMKEFQEWFS GIKAAAKKSS DRTGDSKVLE
AKLRDLQTIL DSVGDGQRKL DAVTQEGQTL YAHLPKQMVS SIQEQITKAN EEFQAFLRQC
LKDKQALQDC ALELGSFEDQ HRKLNLWIHE MNERLSSENS GESKQHIPEK KNEVHRVEMF
LGELLAARES LDKLSQRGQL LSEEGHGAGK EGRLCSQLLT SYQGLVRMTK EKLRRCQAAL
QEHEALEEAL QSMWAWVKGV QDKLACADST VGSKDTLEKR LLQIQDILLM KGEGEVKLNM
AIGKGEQALR SSNKEGQKVI QTQLQTLTDV WANVMSSSVH AQSTLEAVIS QWNDYLEWKH
QLEQWMESVD QKVEHPLKPQ PGLKEKFCLL DHFQCIVSEG EDHAAALHRL TARSRELYQK
TEDASFMETA QEELKTQFND IMTVAKEKMR SAEEMVKDHL LYVDAVQEFT DWLHSAKEEL
HRWSDPSGDS SATQKKLSKI KELMDSRETG ASRLSRVESL APAVKQHTAA SGSELLDAEM
QALRADWKQW EDSVLQTQGS LESLVSQMAL SEQAFSGQVA ALERALEQLS TLLTTWAQQL
ALLEGKNTDQ EIVESWEKGR EILDALQKAE PKTEDLKSQL NELCRFSKDL SPYSGKVSAL
IKEYNCLCLQ ASKGCQNKEQ ILQQRFRRAF KDFQQWLVNA KITTAKCFDI PQNISEVQTS
LQKIQEFSSE SENGQHKLNV MLSKGELLSS LLTKEKANGI QAKIANAKED WKNFHSNLHQ
KESILENLKI QMKDFEVSAE PVQDWLSKTE KMVHESSNRL YDLPAKRREQ QKLQSVLEEI
NCYAPQLHRL KEKAQQLWEG QAASKSFMHR VSQLSAQYLA LSNVTKEKVS RLDRIVAEHS
QFSLGVKELQ DWMTDVVHML ESYCHPTSDK SVLDSRMLKL ESLLSVKQEK EIQMKMIVTR
GESVLQSTAP EGIPALQQQL QSVKDVWASL LSAAIRCKSQ LEGALSKWTS YQDDVRQFSG
WMDSVEASLN ELERPCAELR EKTAALGKAK LLNEEVLSHS SLLETIEVKG AGMTEHYVTQ
LELQDLQERY RAIQERAKEL QVHCAEGQAL LNSVLHTREE VIPSGLPQTE DRALESLRQE
WQAHQQRLSE TRTQFNNVVN KLRLMEQKFQ QVDGWLRTLE QKVSLRAGRQ SNRAAKEAQL
HQMKKWHEEI TTYRDEVEDV GARAQEILDE RRVSSRLGCQ ATQLTSRYQA LLLQVLEQIK
FLEEEIQSLE EAESSLSSYS HWYSSTHKNF KNVAAKIDKV DKAMMGKKMK TLEGLLKDME
KGHSLLKSAR EKGERALAYL EDGEADALRS KIHGHVEQLN ELTSTVRKEH MTLEKGLHLA
KEFSDKYKAL TQWIAEYQEI LHVPEEPKME LYEKKAQLSK YKSLQQTVLS HESSVKSVRE
KGDALLDLVQ DRALKDKIAK LQSDYQALCS AGKDRALKDK IAKLQSDYQA LCSAGKEHVH
SLEVKVKDHE DYNSELQEVE KWLLQMSGRL VAPDLMDTSS LETITQQLAH HKSLQQTVLS
HESSVKSVRE KGDALLDLVQ DRALKDKIAK LQSDYQALCS AGKEHVHSLE VKVKDHEDYN
SELQEVEKWL LQMSGRLVAP DLMDTSSLET ITQQLAHHKA MMEEIAGFED RLNNLKTKGD
TLISQCAEHL QAKLIQHVQA HLQGTRDSYS AICSTAQRAM MEEIAGFEDR LNNLKTKGDT
LISQCAEHLQ AKLIQHVQAH LQGTRDSYSA ICSTAQRVYQ SLEHELQRHV SRQDTLQQCQ
AWLSAIQPDL KPSPHPPLSR AEAVKQVKHF RALQKQARTY LDLLCSMCDL SNSSVKTTAK
DIQQTEQMIE QRLAQAQTLT QGWEEIKHMK AELWIYLQDA DQQLQNMRRR HAELELNIAQ
NMVSQVKDFV KKLQCKQASV TAITEKVDEL TKKQESPEHK EISHLNDQWL DLCLQSNSLC
LQREEDLQRT RDYHDCMSVV EVFLEKFTTE WDNLARSDAE STAVHLEALK KLASALQERK
QAIEDLKDRK QSVIEHLNLD DRDLVKEQTC HLEQRWSQLE DLISRKIQVS VANLEELSVV
QARFQELMEW AEEQQPSIAE ALKQSPPPDV APNLLMDHLT VCSELEAKQM LLKSLTKDAD
RVMADLGLNE RQVIQKALAD AQRHVHCLSD LVGQRRKYLN KALSEKTQFL MALFQATSQI
QQHERKILFR EHICLLPDDV SKQIKACRSA QASLKTYQSE VTGLWAQGRE LMKGATEQDK
GEVLGKLQDL QGVYDAVLQK CSQRLQELEK SFVSRKHFKE DFDKACHWLK QADIVTFPEI
NLMNESSELQ AQLAKYQHLL EQSPEYESLL LTLQRTGQAI LPSLSEVDHS YLDEKLNALP
QQFNVIVALA KDKFYKVQEA ILARKEYASL IELTTQSLSD LEDQFLKMSP VPSALTVEEA
LCLQEGCRVL LGEVVGLGEA VDELSQKKES FRSTGQPWQP DRMLQLVASY HRLKRQTEQR
ASLLEDTTAA YQEHEKMGQQ LWKQLEAVRA EQSQVNEETL PAEEKLKLYH SLAGSLQDSG
ILLKRLAMHL EDLVPHLHPS AYEKAKQQIQ AWQEELTLLT AAIGATVTEC ESRMVQSIDF
QTELSRSLAW LRGVQAELGG PVCLDLNLRD IQEEIRKVQI HQEEVQSSLR IMKALSDKET
ERFTKAKELI SADLQHTLAE LSELDGDIQE ALRTRQATLT QIYSQCQRYY QVFQAASDWL
EDAHEMLQLA GSGLDVESAE DSLRSHTEFF SAEDQFQSNL EELHGLVATL DPLIKPTAKE
ELAQKMTTLE EKSRRVIQDS HAQLDLLRRC AAQWQDYQKA REEVIELMNA AEKKLSEFSL
LKTSSSHEAE EKLSEHKALV SGVHSFHEKI VALEGEASQL EKAGNDASKA TIGRSMTTVW
QRWARLRAVA QDQEKILEDA ADAWKNLGKK VKKATDTINQ LEGKLPGSSA EKASKVELLA
LLEHHDTFTL ELDQQQAALG MLRQQALSML PDGATPPPGE EPPVMQEITA MQDRCLNMQE
KVRSHGKVVK RELKDREGVE TQINSVKSWV RETKEYLENP TIEIDAQLEE LQILLTEATK
HRQNIEAVTE EQKTKYLGLY AILPSELSLQ LAEVALNLGT VHDQIQDRVK QIEQSKATSQ
EFSQQIQKIT KDLTTILTKL RAKTDNLVQA KADQKVLGEE LDACNLKLME LDGAIQKFSE
QNGQLGKPLT KKVGKLTELH QQTSRQAETR FFKLSQATSH LEEYNELLEF ILKWIDKAKV
LVHAKIVWNS AKQLREQYIS HQVTWVKIVF KE
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