ID S7QBH0_MYOBR Unreviewed; 766 AA.
AC S7QBH0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=X-ray repair cross-complementing protein 5 {ECO:0000313|EMBL:EPQ18407.1};
GN ORFNames=D623_10032862 {ECO:0000313|EMBL:EPQ18407.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18407.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; KE164532; EPQ18407.1; -; Genomic_DNA.
DR AlphaFoldDB; S7QBH0; -.
DR eggNOG; KOG2326; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR CDD; cd01458; vWA_ku; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 309..448
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 766 AA; 86854 MW; 91A5F56FF7ADAEB4 CRC64;
MVSTYSTGLY NFKEAAVVLC MDVGFAMSNS FPGEESPFEL AKKVMTMFVQ RQVFAESKDE
IALVLFGTDG TENALACEDQ YQNITVHRHL MLPDFNLLED IESKIQPGSQ QADFLDALIV
CMDVIQQETV GKKFEKRHIE VFTDLSSPFS KDQLDTIIHN LKKSNISLQF FLPFPIGKED
GAGDRGDGNL PLDNHGPSFP LKGITEQQKE GIRMVKRVMM SLEGEDGLDE IYSFSESLRQ
LCVFKKTERS SMAWPCQLTI GSNLSIKILA YKSILQEKVK KSWIVVDART LKKEDVKKET
VYCLNDDDET EVPKEDTIQG FRYGSDIIPF SKVDEEQMKY KSEGKCFSVL GFCRSSQVHR
KYFMGNQVLK VFAAKDDEAA AVALSSLIHA LDELAMVAIV RYAYDRRSNP QVGVAFPHIK
DTYECLVYVQ LPFMEDLRQY MFSSLKNNKK YTPTEAQLSA VDALIDSMSL VKKDEEGDTI
EDLFPTTKIP NPQFQRLFQC LLHRALHPQE PLPPVQQHVL NMLDPPTEVT ANCEIPLSKI
KTLFPLTEAI KKKDQLTAQD VFQDKHEEGP TSKKLKTEEE AHFSLSSLAE GTVTKVGSVN
PAENFRVLVR QKNASFEEAS RQLISHIEQF LDTKETPYFM KSMDCIKAFR EEAIQFSEDQ
RFNNFLKDLR EKVEIKQLNN FWEIIIQDGI TLITKDEASG SSVTAEEAKK FLAPKENPNE
ERAALFEEGG DVDDLVWELS ASKAHMAWQP SSNSCQLSME KLLALQ
//
