ID S7QFP2_MYOBR Unreviewed; 1073 AA.
AC S7QFP2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=NLR family CARD domain-containing protein 4 {ECO:0000256|ARBA:ARBA00015338};
DE AltName: Full=Ice protease-activating factor {ECO:0000256|ARBA:ARBA00030378};
GN ORFNames=D623_10019010 {ECO:0000313|EMBL:EPQ20127.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20127.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164790; EPQ20127.1; -; Genomic_DNA.
DR AlphaFoldDB; S7QFP2; -.
DR eggNOG; ENOG502QWRJ; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.1900.50; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR042220; NLRC4.
DR InterPro; IPR040535; NLRC4_HD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47688; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR47688:SF1; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17889; NLRC4_HD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 25..111
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 186..275
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1073 AA; 120652 MW; 1D2C624D51008ADD CRC64;
MDCLGTVWSA FDRNGIASPG TTRVNFIKEN SQALIQRMGM TVIKQVVDEL FVWNVLNFEE
VNIICCEKVE QDAARGIIHM LLKKGSEACN LFLKSLEKWN YPLFQDLNGQ SLFHQMSDGD
LDDLAQDLKD LYHSPYFLNF YPLGEDIDII FNLKSTFTEP VLWRKDQRHH RLEQLTLSGL
LDTLQSPCII EGESGKGKTT LLQRIAMLWA SGKCGALTKF KLVFFLRLSR AHGGLFETLC
DQLLDVPDPI RKQTFMAMLL KLRQRVLFLL DGYNEFKAQN CPEIEALIKE NHRFKNMVMV
TTTTESLKHI RQFGALTAEV GDMTEESAQA LIREVLIREH AESLVLQIQK SRCLRNLMKT
PLFVVITCAI QMGESEFHSH TQTTLFCTFY DLLIQKNKHK HRGVAASDLT QSLDHCGDLA
LEGVFNHRFD FESKDVCSVN EDVLLTTGLL CKYTAQRFKP KYKFFHQSFQ EYIAGRRLSS
LLASREPEEV TKGNGHLQKM VSISDITSKY SNLLLYTCGS STEATRTVLK HLAAVCQHGS
LPSFSITKRP LWRQESMQNV KSTTVQEILE AINTSSFTEC GINLFHESIS KADLSEEFEA
FFRGKSLYIN SENIPDYLFD FFEHLPNCAS ALDFIKLDFY GGATASWDKP TEGTSRTHKE
ESSGTYIPSR AVSLFFNWKQ EFKTLEVTLR DFSKLNKQDI KYLGKIFSSA TSLRLSIKRC
AGVAGSLSLV LSTCKHIHSL VVEASPLTIE DEQHITSVAN LKTLSIHNLQ TQRLPGGLTD
SLGNLKNLMK LMLDNIKMNE EDAIKLAEGL TDLKNMCLLR LTHLSDIGEG MDYIAKSLSA
KPCDLEEIQL VSCCLTGTAV KTLAQNLHNL AKLSILDLSE NHLEEDGNEA LSELSKNDHF
ALEMHLKEVS FEMDPVSELS LVPQVDRLHV LEQLTVLMLP WCTDVRVSLT RLLEQLEGAP
QLVKLGLKNW RLTDAEIRIL VPSASIPAPR RCQDWVQASV AALIAPQEQG EVEKPSGAMR
TSSCHSHPLM VPSHWDQCRA LAVGASGAVA GRGCEQRLLA PTSPQEQGEV EKP
//
